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Target
Pannexin-1
Ligand
BDBM50247012
Substrate
n/a
Meas. Tech.
ChEMBL_2122674 (CHEMBL4831907)
IC50
10000±n/a nM
Citation
 Crocetti, L; Guerrini, G; Puglioli, S; Giovannoni, MP; Di Cesare Mannelli, L; Lucarini, E; Ghelardini, C; Wang, J; Dahl, G Design and synthesis of the first indole-based blockers of Panx-1 channel. Eur J Med Chem 223:0 (2021) [PubMed]  Article 
Target
Name:
Pannexin-1
Synonyms:
PANX1_MOUSE | Pannexin-1 | Panx1
Type:
PROTEIN
Mol. Mass.:
48168.73
Organism:
Mus musculus
Description:
ChEMBL_120484
Residue:
426
Sequence:
MAIAHLATEYVFSDFLLKEPTEPKFKGLRLELAVDKMVTCIAVGLPLLLISLAFAQEISIGTQISCFSPSSFSWRQAAFVDSYCWAAVQQKSSLQSESGNLPLWLHKFFPYILLLFAILLYLPALFWRFSAAPHLCSDLKFIMEELDKVYNRAIKAAKSARDLDLRDGPGPPGVTENVGQSLWEISESHFKYPIVEQYLKTKKNSSHLIMKYISCRLVTFVVILLACIYLSYYFSLSSLSDEFLCSIKSGVLKNDSTIPDRFQCKLIAVGIFQLLSLINLIVYALLIPVVVYTFFIPFRQKTDILKVYEILPTFDVLHFKSEGYNDLSLYNLFLEENISELKSYKCLKVLENIKSNGQGIDPMLLLTNLGMIKMDIIDGKIPTSLQTKGEDQGSQRVEFKDLDLSSEAAANNGEKNSRQRLLNPSC
  
Inhibitor
Name:
BDBM50247012
Synonyms:
3beta-O-Succinyl-18-beta-glycyrrhetinic acid | Carbenoxolone | US11660306, Example Carbeanoxolone
Type:
Small organic molecule
Emp. Form.:
C34H50O7
Mol. Mass.:
570.7566
SMILES:
CC1(C)[C@H](CC[C@@]2(C)[C@H]1CC[C@]1(C)[C@@H]2C(=O)C=C2[C@@H]3C[C@](C)(CC[C@]3(C)CC[C@@]12C)C(O)=O)OC(=O)CCC(O)=O |r,t:18|
Structure:
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