Reaction Details Report a problem with these data
Target
Substance-P receptor
Ligand
BDBM50140773
Substrate
n/a
Meas. Tech.
ChEMBL_205578 (CHEMBL812542)
IC50
0.01±n/a nM
Citation
 Cappelli, A; Giuliani, G; Pericot Mohr Gl, G; Gallelli, A; Anzini, M; Vomero, S; Cupello, A; Scarrone, S; Matarrese, M; Moresco, RM; Fazio, F; Finetti, F; Morbidelli, L; Ziche, M A non-peptide NK1 receptor agonist showing subpicomolar affinity. J Med Chem 47:1315-8 (2004) [PubMed]  Article 
Target
Name:
Substance-P receptor
Synonyms:
NK-1 receptor | NK-1R | NK1 Receptor | NK1R | NK1R_HUMAN | Neurokinin 1 receptor | Neurokinin-1 (NK-1) | Neuromedin-1 receptor (NK-1R) | SPR | TAC1R | TACR1 | Tachykinin receptor 1 | Tachykinin receptor 1 (NK1) | tachykinin
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
46254.43
Organism:
Homo sapiens (Human)
Description:
P25103
Residue:
407
Sequence:
MDNVLPVDSDLSPNISTNTSEPNQFVQPAWQIVLWAAAYTVIVVTSVVGNVVVMWIILAHKRMRTVTNYFLVNLAFAEASMAAFNTVVNFTYAVHNEWYYGLFYCKFHNFFPIAAVFASIYSMTAVAFDRYMAIIHPLQPRLSATATKVVICVIWVLALLLAFPQGYYSTTETMPSRVVCMIEWPEHPNKIYEKVYHICVTVLIYFLPLLVIGYAYTVVGITLWASEIPGDSSDRYHEQVSAKRKVVKMMIVVVCTFAICWLPFHIFFLLPYINPDLYLKKFIQQVYLAIMWLAMSSTMYNPIIYCCLNDRFRLGFKHAFRCCPFISAGDYEGLEMKSTRYLQTQGSVYKVSRLETTISTVVGAHEEEPEDGPKATPSSLDLTSNCSSRSDSKTMTESFSFSSNVLS
  
Inhibitor
Name:
BDBM50140773
Synonyms:
2-Bromomethyl-4-phenyl-quinoline-3-carboxylic acid 3,5-bis-trifluoromethyl-benzylamide | CHEMBL281797
Type:
Small organic molecule
Emp. Form.:
C26H17BrF6N2O
Mol. Mass.:
567.32
SMILES:
FC(F)(F)c1cc(CNC(=O)c2c(CBr)nc3ccccc3c2-c2ccccc2)cc(c1)C(F)(F)F
Structure:
Search PDB for entries with ligand similarity: