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Target
Substance-P receptor
Ligand
BDBM50140788
Substrate
n/a
Meas. Tech.
ChEMBL_205578 (CHEMBL812542)
IC50
9±n/a nM
Citation
 Cappelli, A; Giuliani, G; Pericot Mohr Gl, G; Gallelli, A; Anzini, M; Vomero, S; Cupello, A; Scarrone, S; Matarrese, M; Moresco, RM; Fazio, F; Finetti, F; Morbidelli, L; Ziche, M A non-peptide NK1 receptor agonist showing subpicomolar affinity. J Med Chem 47:1315-8 (2004) [PubMed]  Article 
Target
Name:
Substance-P receptor
Synonyms:
NK-1 receptor | NK-1R | NK1 Receptor | NK1R | NK1R_HUMAN | Neurokinin 1 receptor | Neurokinin-1 (NK-1) | Neuromedin-1 receptor (NK-1R) | SPR | TAC1R | TACR1 | Tachykinin receptor 1 | Tachykinin receptor 1 (NK1) | tachykinin
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
46254.43
Organism:
Homo sapiens (Human)
Description:
P25103
Residue:
407
Sequence:
MDNVLPVDSDLSPNISTNTSEPNQFVQPAWQIVLWAAAYTVIVVTSVVGNVVVMWIILAHKRMRTVTNYFLVNLAFAEASMAAFNTVVNFTYAVHNEWYYGLFYCKFHNFFPIAAVFASIYSMTAVAFDRYMAIIHPLQPRLSATATKVVICVIWVLALLLAFPQGYYSTTETMPSRVVCMIEWPEHPNKIYEKVYHICVTVLIYFLPLLVIGYAYTVVGITLWASEIPGDSSDRYHEQVSAKRKVVKMMIVVVCTFAICWLPFHIFFLLPYINPDLYLKKFIQQVYLAIMWLAMSSTMYNPIIYCCLNDRFRLGFKHAFRCCPFISAGDYEGLEMKSTRYLQTQGSVYKVSRLETTISTVVGAHEEEPEDGPKATPSSLDLTSNCSSRSDSKTMTESFSFSSNVLS
  
Inhibitor
Name:
BDBM50140788
Synonyms:
2-Aminomethyl-4-phenyl-quinoline-3-carboxylic acid (3,5-bis-trifluoromethyl-benzyl)-methyl-amide | CHEMBL25521
Type:
Small organic molecule
Emp. Form.:
C27H21F6N3O
Mol. Mass.:
517.4656
SMILES:
CN(Cc1cc(cc(c1)C(F)(F)F)C(F)(F)F)C(=O)c1c(CN)nc2ccccc2c1-c1ccccc1
Structure:
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