Reaction Details Report a problem with these data
Target
Type-2 angiotensin II receptor
Ligand
BDBM50141048
Substrate
n/a
Meas. Tech.
ChEMBL_35278 (CHEMBL648317)
Ki
8±n/a nM
Citation
 Wan, Y; Wallinder, C; Johansson, B; Holm, M; Mahalingam, AK; Wu, X; Botros, M; Karlén, A; Pettersson, A; Nyberg, F; Fändriks, L; Hallberg, A; Alterman, M First reported nonpeptide AT1 receptor agonist (L-162,313) acts as an AT2 receptor agonist in vivo. J Med Chem 47:1536-46 (2004) [PubMed]  Article 
Target
Name:
Type-2 angiotensin II receptor
Synonyms:
AGTR2 | AGTR2_HUMAN | AT2 | Angiotensin II receptor | Angiotensin II type 2 (AT-2) receptor | Angiotensin II, central | Type-2 angiotensin II receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
41201.61
Organism:
Homo sapiens (Human)
Description:
Angiotensin II, central 0 0::P50052
Residue:
363
Sequence:
MKGNSTLATTSKNITSGLHFGLVNISGNNESTLNCSQKPSDKHLDAIPILYYIIFVIGFLVNIVVVTLFCCQKGPKKVSSIYIFNLAVADLLLLATLPLWATYYSYRYDWLFGPVMCKVFGSFLTLNMFASIFFITCMSVDRYQSVIYPFLSQRRNPWQASYIVPLVWCMACLSSLPTFYFRDVRTIEYLGVNACIMAFPPEKYAQWSAGIALMKNILGFIIPLIFIATCYFGIRKHLLKTNSYGKNRITRDQVLKMAAAVVLAFIICWLPFHVLTFLDALAWMGVINSCEVIAVIDLALPFAILLGFTNSCVNPFLYCFVGNRFQQKLRSVFRVPITWLQGKRESMSCRKSSSLREMETFVS
  
Inhibitor
Name:
BDBM50141048
Synonyms:
CHEMBL287829 | N-Butyloxycarbonyl-5-isobutyl-3-(4-{6-[N-(thiophene-2-carbonyl)ethylamino]-4-oxo-2-propyl-4H-quinazolin-3-ylmethyl}phenyl)-thiophene-2-sulfonamide
Type:
Small organic molecule
Emp. Form.:
C38H44N4O6S3
Mol. Mass.:
748.974
SMILES:
CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2c(CCC)nc3ccc(cc3c2=O)N(CC)C(=O)c2cccs2)cc1
Structure:
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