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Target
Polycomb protein EED
Ligand
BDBM50575302
Substrate
n/a
Meas. Tech.
ChEMBL_2124802 (CHEMBL4834035)
IC50
7.9±n/a nM
Citation
 Bagal, SK; Gregson, C; O' Donovan, DH; Pike, KG; Bloecher, A; Barton, P; Borodovsky, A; Code, E; Fillery, SM; Hsu, JH; Kawatkar, SP; Li, C; Longmire, D; Nai, Y; Nash, SC; Pike, A; Robinson, J; Read, JA; Rawlins, PB; Shen, M; Tang, J; Wang, P; Woods, H; Williamson, B Diverse, Potent, and Efficacious Inhibitors That Target the EED Subunit of the Polycomb Repressive Complex 2 Methyltransferase. J Med Chem 64:17146-17183 (2021) [PubMed]  Article 
Target
Name:
Polycomb protein EED
Synonyms:
EED | EED_HUMAN | WAIT-1 | WD protein associating with integrin cytoplasmic tails 1 | hEED
Type:
Protein
Mol. Mass.:
50201.68
Organism:
Homo sapiens (Human)
Description:
O75530
Residue:
441
Sequence:
MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR
  
Inhibitor
Name:
BDBM50575302
Synonyms:
CHEMBL4847216
Type:
Small organic molecule
Emp. Form.:
C24H21FN6O3
Mol. Mass.:
460.4603
SMILES:
CNC(=O)c1ccc(c(C)n1)-c1cnc(NCc2c3CCOc3ccc2F)c2cn[nH]c(=O)c12
Structure:
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