Reaction Details Report a problem with these data
Target
Melatonin receptor type 1B
Ligand
BDBM103449
Substrate
n/a
Meas. Tech.
ChEMBL_2125810 (CHEMBL4835155)
Ki
0.086000±n/a nM
Citation
 Hoashi, Y; Takai, T; Kosugi, Y; Nakashima, M; Nakayama, M; Hirai, K; Uchikawa, O; Koike, T Discovery of a Potent and Orally Bioavailable Melatonin Receptor Agonist. J Med Chem 64:3059-3074 (2021) [PubMed]  Article 
Target
Name:
Melatonin receptor type 1B
Synonyms:
MTNR1B | MTR1B_HUMAN | Mel-1B-R | Mel1b melatonin receptor | Melatonin 1B | Melatonin receptor | Melatonin receptor type 1B | Melatonin receptor type 2 (MT2)
Type:
Enzyme
Mol. Mass.:
40203.54
Organism:
Homo sapiens (Human)
Description:
P49286
Residue:
362
Sequence:
MSENGSFANCCEAGGWAVRPGWSGAGSARPSRTPRPPWVAPALSAVLIVTTAVDVVGNLLVILSVLRNRKLRNAGNLFLVSLALADLVVAFYPYPLILVAIFYDGWALGEEHCKASAFVMGLSVIGSVFNITAIAINRYCYICHSMAYHRIYRRWHTPLHICLIWLLTVVALLPNFFVGSLEYDPRIYSCTFIQTASTQYTAAVVVIHFLLPIAVVSFCYLRIWVLVLQARRKAKPESRLCLKPSDLRSFLTMFVVFVIFAICWAPLNCIGLAVAINPQEMAPQIPEGLFVTSYLLAYFNSCLNAIVYGLLNQNFRREYKRILLALWNPRHCIQDASKGSHAEGLQSPAPPIIGVQHQADAL
  
Inhibitor
Name:
BDBM103449
Synonyms:
US8552037, 97
Type:
Small organic molecule
Emp. Form.:
C15H18N2OS
Mol. Mass.:
274.381
SMILES:
CC(=O)NCCC1CCc2ccc3nc(C)sc3c12
Structure:
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