Reaction Details Report a problem with these data
Target
Carboxypeptidase B
Ligand
BDBM50575780
Substrate
n/a
Meas. Tech.
ChEMBL_2125970 (CHEMBL4835315)
Ki
5300±n/a nM
Citation
 Schaffner, AP; Sansilvestri-Morel, P; Despaux, N; Ruano, E; Persigand, T; Rupin, A; Mennecier, P; Vallez, MO; Raimbaud, E; Desos, P; Gloanec, P Phosphinanes and Azaphosphinanes as Potent and Selective Inhibitors of Activated Thrombin-Activatable Fibrinolysis Inhibitor (TAFIa). J Med Chem 64:3897-3910 (2021) [PubMed]  Article 
Target
Name:
Carboxypeptidase B
Synonyms:
CBPB1_HUMAN | CPB | CPB1 | Carboxypeptidase B | PASP | PCPB | Pancreas-specific protein | Thrombin-activatable fibrinolysis (TAFI)
Type:
Enzyme
Mol. Mass.:
47367.43
Organism:
Homo sapiens (Human)
Description:
P15086
Residue:
417
Sequence:
MLALLVLVTVALASAHHGGEHFEGEKVFRVNVEDENHINIIRELASTTQIDFWKPDSVTQIKPHSTVDFRVKAEDTVTVENVLKQNELQYKVLISNLRNVVEAQFDSRVRATGHSYEKYNKWETIEAWTQQVATENPALISRSVIGTTFEGRAIYLLKVGKAGQNKPAIFMDCGFHAREWISPAFCQWFVREAVRTYGREIQVTELLDKLDFYVLPVLNIDGYIYTWTKSRFWRKTRSTHTGSSCIGTDPNRNFDAGWCEIGASRNPCDETYCGPAAESEKETKALADFIRNKLSSIKAYLTIHSYSQMMIYPYSYAYKLGENNAELNALAKATVKELASLHGTKYTYGPGATTIYPAAGGSDDWAYDQGIRYSFTFELRDTGRYGFLLPESQIRATCEETFLAIKYVASYVLEHLY
  
Inhibitor
Name:
BDBM50575780
Synonyms:
CHEMBL4878039
Type:
Small organic molecule
Emp. Form.:
C20H28FN4O4P
Mol. Mass.:
438.4329
SMILES:
Cn1cncc1-c1cc(F)ccc1CN1CCP(O)(=O)[C@@](CCCCN)(C1)C(O)=O |r|
Structure:
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