Reaction Details Report a problem with these data
Target
Neuropeptide Y receptor type 1
Ligand
BDBM50142765
Substrate
n/a
Meas. Tech.
ChEBML_143685
IC50
63±n/a nM
Citation
 Sato, N; Shibata, T; Jitsuoka, M; Ohno, T; Takahashi, T; Hirohashi, T; Kanno, T; Iwaasa, H; Kanatani, A; Fukami, T Synthesis and evaluation of substituted 4-alkoxy-2-aminopyridines as novel neuropeptide Y1 receptor antagonists. Bioorg Med Chem Lett 14:1761-4 (2004) [PubMed]  Article 
Target
Name:
Neuropeptide Y receptor type 1
Synonyms:
NPY-Y1 | NPY1-R | NPY1R | NPY1R_HUMAN | NPYR | NPYY1 | neuropeptide Y receptor Y1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
44399.07
Organism:
Homo sapiens (Human)
Description:
NPY-Y1 NPY1R HUMAN::P25929
Residue:
384
Sequence:
MNSTLFSQVENHSVHSNFSEKNAQLLAFENDDCHLPLAMIFTLALAYGAVIILGVSGNLALIIIILKQKEMRNVTNILIVNLSFSDLLVAIMCLPFTFVYTLMDHWVFGEAMCKLNPFVQCVSITVSIFSLVLIAVERHQLIINPRGWRPNNRHAYVGIAVIWVLAVASSLPFLIYQVMTDEPFQNVTLDAYKDKYVCFDQFPSDSHRLSYTTLLLVLQYFGPLCFIFICYFKIYIRLKRRNNMMDKMRDNKYRSSETKRINIMLLSIVVAFAVCWLPLTIFNTVFDWNHQIIATCNHNLLFLLCHLTAMISTCVNPIFYGFLNKNFQRDLQFFFNFCDFRSRDDDYETIAMSTMHTDVSKTSLKQASPVAFKKINNNDDNEKI
  
Inhibitor
Name:
BDBM50142765
Synonyms:
CHEMBL51422 | [3-Chloro-5-({6-[2-(5-ethyl-4-methyl-thiazol-2-yl)-ethyl]-4-hexyloxy-pyridin-2-ylamino}-methyl)-phenyl]-carbamic acid isopropyl ester
Type:
Small organic molecule
Emp. Form.:
C30H41ClN4O3S
Mol. Mass.:
573.19
SMILES:
CCCCCCOc1cc(CCc2nc(C)c(CC)s2)nc(NCc2cc(Cl)cc(NC(=O)OC(C)C)c2)c1
Structure:
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