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Target
STE20-like serine/threonine-protein kinase
Ligand
BDBM50577331
Substrate
n/a
Meas. Tech.
ChEMBL_2129997 (CHEMBL4839426)
Ki
29±n/a nM
Citation
 Serafim, RAM; Sorrell, FJ; Berger, BT; Collins, RJ; Vasconcelos, SNS; Massirer, KB; Knapp, S; Bennett, J; Fedorov, O; Patel, H; Zuercher, WJ; Elkins, JM Discovery of a Potent Dual SLK/STK10 Inhibitor Based on a Maleimide Scaffold. J Med Chem 64:13259-13278 (2021) [PubMed]  Article 
Target
Name:
STE20-like serine/threonine-protein kinase
Synonyms:
KIAA0204 | SLK | SLK_HUMAN | STK2 | Serine/threonine-protein kinase 2
Type:
PROTEIN
Mol. Mass.:
142644.38
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1451342
Residue:
1235
Sequence:
MSFFNFRKIFKLGSEKKKKQYEHVKRDLNPEDFWEIIGELGDGAFGKVYKAQNKETSVLAAAKVIDTKSEEELEDYMVEIDILASCDHPNIVKLLDAFYYENNLWILIEFCAGGAVDAVMLELERPLTESQIQVVCKQTLDALNYLHDNKIIHRDLKAGNILFTLDGDIKLADFGVSAKNTRTIQRRDSFIGTPYWMAPEVVMCETSKDRPYDYKADVWSLGITLIEMAEIEPPHHELNPMRVLLKIAKSEPPTLAQPSRWSSNFKDFLKKCLEKNVDARWTTSQLLQHPFVTVDSNKPIRELIAEAKAEVTEEVEDGKEEDEEEETENSLPIPASKRASSDLSIASSEEDKLSQNACILESVSEKTERSNSEDKLNSKILNEKPTTDEPEKAVEDINEHITDAQLEAMTELHDRTAVIKENEREKRPKLENLPDTEDQETVDINSVSEGKENNIMITLETNIEHNLKSEEEKDQEKQQMFENKLIKSEEIKDTILQTVDLVSQETGEKEANIQAVDSEVGLTKEDTQEKLGEDDKTQKDVISNTSDVIGTCEAADVAQKVDEDSAEDTQSNDGKEVVEVGQKLINKPMVGPEAGGTKEVPIKEIVEMNEIEEGKNKEQAINSSENIMDINEEPGTTEGEEITESSSTEEMEVRSVVADTDQKALGSEVQDASKVTTQIDKEKKEIPVSIKKEPEVTVVSQPTEPQPVLIPSININSDSGENKEEIGSLSKTETILPPESENPKENDNDSGTGSTADTSSIDLNLSISSFLSKTKDSGSISLQETRRQKKTLKKTRKFIVDGVEVSVTTSKIVTDSDSKTEELRFLRRQELRELRFLQKEEQRAQQQLNSKLQQQREQIFRRFEQEMMSKKRQYDQEIENLEKQQKQTIERLEQEHTNRLRDEAKRIKGEQEKELSKFQNMLKNRKKEVINEVEKAPKELRKELMKRRKEELAQSQHAQEQEFVQKQQQELDGSLKKIIQQQKAELANIERECLNNKQQLMRAREAAIWELEERHLQEKHQLLKQQLKDQYFMQRHQLLKRHEKETEQMQRYNQRLIEELKNRQTQERARLPKIQRSEAKTRMAMFKKSLRINSTATPDQDRDKIKQFAAQEEKRQKNERMAQHQKHENQMRDLQLQCEANVRELHQLQNEKCHLLVEHETQKLKELDEEHSQELKEWREKLRPRKKTLEEEFARKLQEQEVFFKMTGESECLNPSTQSRISKFYPIPSLHSTGS
  
Inhibitor
Name:
BDBM50577331
Synonyms:
CHEMBL4877101
Type:
Small organic molecule
Emp. Form.:
C21H13N3O2
Mol. Mass.:
339.3468
SMILES:
O=C1NC(=O)C(=C1Nc1cccc(c1)C#N)c1cccc2ccccc12 |c:5|
Structure:
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