Reaction Details Report a problem with these data
Target
NAD-dependent protein deacetylase sirtuin-3, mitochondrial
Ligand
BDBM50577534
Substrate
n/a
Meas. Tech.
ChEMBL_2130517 (CHEMBL4839946)
EC50
17390±n/a nM
Citation
 Zhang, J; Zou, L; Shi, D; Liu, J; Zhang, J; Zhao, R; Wang, G; Zhang, L; Ouyang, L; Liu, B Structure-Guided Design of a Small-Molecule Activator of Sirtuin-3 that Modulates Autophagy in Triple Negative Breast Cancer. J Med Chem 64:14192-14216 (2021) [PubMed]  Article 
Target
Name:
NAD-dependent protein deacetylase sirtuin-3, mitochondrial
Synonyms:
NAD-dependent deacetylase sirtuin 3 | NAD-dependent protein deacetylase sirtuin-3 (SIRT3) | SIR2L3 | SIR3_HUMAN | SIRT3
Type:
Protein
Mol. Mass.:
43582.69
Organism:
Homo sapiens (Human)
Description:
Q9NTG7
Residue:
399
Sequence:
MAFWGWRAAAALRLWGRVVERVEAGGGVGPFQACGCRLVLGGRDDVSAGLRGSHGARGEPLDPARPLQRPPRPEVPRAFRRQPRAAAPSFFFSSIKGGRRSISFSVGASSVVGSGGSSDKGKLSLQDVAELIRARACQRVVVMVGAGISTPSGIPDFRSPGSGLYSNLQQYDLPYPEAIFELPFFFHNPKPFFTLAKELYPGNYKPNVTHYFLRLLHDKGLLLRLYTQNIDGLERVSGIPASKLVEAHGTFASATCTVCQRPFPGEDIRADVMADRVPRCPVCTGVVKPDIVFFGEPLPQRFLLHVVDFPMADLLLILGTSLEVEPFASLTEAVRSSVPRLLINRDLVGPLAWHPRSRDVAQLGDVVHGVESLVELLGWTEEMRDLVQRETGKLDGPDK
  
Inhibitor
Name:
BDBM50577534
Synonyms:
CHEMBL4877287
Type:
Small organic molecule
Emp. Form.:
C29H29NO4
Mol. Mass.:
455.5449
SMILES:
CCCCc1oc2ccccc2c1C(=O)c1ccc(OCC(=O)N[C@H](C)c2ccccc2)cc1 |r|
Structure:
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