Reaction Details Report a problem with these data
Target
Type-1 angiotensin II receptor B
Ligand
BDBM50049186
Substrate
n/a
Meas. Tech.
ChEMBL_34817 (CHEMBL648961)
IC50
1.9±n/a nM
Citation
 Cappelli, A; Pericot Mohr Gl, G; Gallelli, A; Rizzo, M; Anzini, M; Vomero, S; Mennuni, L; Ferrari, F; Makovec, F; Menziani, MC; De Benedetti, PG; Giorgi, G Design, synthesis, structural studies, biological evaluation, and computational simulations of novel potent AT(1) angiotensin II receptor antagonists based on the 4-phenylquinoline structure. J Med Chem 47:2574-86 (2004) [PubMed]  Article 
Target
Name:
Type-1 angiotensin II receptor B
Synonyms:
AGTRB_RAT | AT3 | Agtr1 | Agtr1b | Angiotensin II AT1B | Angiotensin II receptor (AT-1) type-1 | Angiotensin II type 1b (AT-1b) receptor | At1b | Type-1B angiotensin II receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
40929.44
Organism:
RAT
Description:
Angiotensin II AT1B 0 RAT::P29089
Residue:
359
Sequence:
MTLNSSTEDGIKRIQDDCPKAGRHNYIFVMIPTLYSIIFVVGIFGNSLVVIVIYFYMKLKTVASVFLLNLALADLCFLLTLPLWAVYTAMEYRWPFGNHLCKIASASVSFNLYASVFLLTCLSIDRYLAIVHPMKSRLRRTMLVAKVTCIIIWLMAGLASLPAVIYRNVYFIENTNITVCAFHYESQNSTLPIGLGLTKNILGFVFPFLIILTSYTLIWKALKKAYKIQKNTPRNDDIFRIIMAIVLFFFFSWVPHQIFTFLDVLIQLGIIRDCEIADIVDTAMPITICIAYFNNCLNPLFYGFLGKKFKKYFLQLLKYIPPTAKSHAGLSTKMSTLSYRPSDNMSSSAKKSASFFEVE
  
Inhibitor
Name:
BDBM50049186
Synonyms:
(S)-3-Methyl-2-{pentanoyl-[2'-(1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-amino}-butyric acid | (S)-3-Methyl-2-{pentanoyl-[2'-(2H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-amino}-butyric acid | 2-{[2'-(2,3-Dihydro-1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-pentanoyl-amino}-3-methyl-butyric acid | 3-Methyl-2-{((S)-pentanoyl)-[2'-(1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-amino}-butyric acid | 3-Methyl-2-{pentanoyl-[2'-(1H-tetrazol-5-yl)-biphenyl-4-yl]-amino}-butyric acid | CGP-48933 | CHEMBL1069 | Diovan | Exforge | Prexxartan | VALSARTAN
Type:
Small organic molecule
Emp. Form.:
C24H29N5O3
Mol. Mass.:
435.5188
SMILES:
CCCCC(=O)N(Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1)[C@@H](C(C)C)C(O)=O
Structure:
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