Reaction Details Report a problem with these data
Target
Type-1 angiotensin II receptor B
Ligand
BDBM50145983
Substrate
n/a
Meas. Tech.
ChEMBL_34817 (CHEMBL648961)
IC50
106±n/a nM
Citation
Cappelli, A; Pericot Mohr Gl, G; Gallelli, A; Rizzo, M; Anzini, M; Vomero, S; Mennuni, L; Ferrari, F; Makovec, F; Menziani, MC; De Benedetti, PG; Giorgi, G Design, synthesis, structural studies, biological evaluation, and computational simulations of novel potent AT(1) angiotensin II receptor antagonists based on the 4-phenylquinoline structure. J Med Chem 47:2574-86 (2004) [PubMed] Article
More Info.:
Target
Name:
Type-1 angiotensin II receptor B
Synonyms:
AGTRB_RAT | AT3 | Agtr1 | Agtr1b | Angiotensin II AT1B | Angiotensin II receptor (AT-1) type-1 | Angiotensin II type 1b (AT-1b) receptor | At1b | Type-1B angiotensin II receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
40929.44
Organism:
RAT
Description:
Angiotensin II AT1B 0 RAT::P29089
Residue:
359
Sequence:
MTLNSSTEDGIKRIQDDCPKAGRHNYIFVMIPTLYSIIFVVGIFGNSLVVIVIYFYMKLKTVASVFLLNLALADLCFLLTLPLWAVYTAMEYRWPFGNHLCKIASASVSFNLYASVFLLTCLSIDRYLAIVHPMKSRLRRTMLVAKVTCIIIWLMAGLASLPAVIYRNVYFIENTNITVCAFHYESQNSTLPIGLGLTKNILGFVFPFLIILTSYTLIWKALKKAYKIQKNTPRNDDIFRIIMAIVLFFFFSWVPHQIFTFLDVLIQLGIIRDCEIADIVDTAMPITICIAYFNNCLNPLFYGFLGKKFKKYFLQLLKYIPPTAKSHAGLSTKMSTLSYRPSDNMSSSAKKSASFFEVE
Inhibitor
Name:
BDBM50145983
Synonyms:
CHEMBL83414 | N-{4-[4-(5,7-Dimethyl-2-propyl-imidazo[4,5-b]pyridin-3-ylmethyl)-phenyl]-quinoline-3-carbonyl}-4-nitro-benzenesulfonamide
Type:
Small organic molecule
Emp. Form.:
C34H30N6O5S
Mol. Mass.:
634.704
SMILES:
CCCc1nc2c(C)cc(C)nc2n1Cc1ccc(cc1)-c1c(cnc2ccccc12)C(=O)NS(=O)(=O)c1ccc(cc1)[N+]([O-])=O