Reaction Details Report a problem with these data
Target
Cathepsin B
Ligand
BDBM50148310
Substrate
n/a
Meas. Tech.
ChEBML_47415
IC50
72±n/a nM
Citation
 Boros, EE; Deaton, DN; Hassell, AM; McFadyen, RB; Miller, AB; Miller, LR; Paulick, MG; Shewchuk, LM; Thompson, JB; Willard, DH; Wright, LL Exploration of the P2-P3 SAR of aldehyde cathepsin K inhibitors. Bioorg Med Chem Lett 14:3425-9 (2004) [PubMed]  Article 
Target
Name:
Cathepsin B
Synonyms:
APP secretase | APPS | CATB_HUMAN | CPSB | CTSB | Cathepsin B heavy chain | Cathepsin B light chain | Cathepsin B1
Type:
Enzyme
Mol. Mass.:
37819.69
Organism:
Homo sapiens (Human)
Description:
gi_63102437
Residue:
339
Sequence:
MWQLWASLCCLLVLANARSRPSFHPLSDELVNYVNKRNTTWQAGHNFYNVDMSYLKRLCGTFLGGPKPPQRVMFTEDLKLPASFDAREQWPQCPTIKEIRDQGSCGSCWAFGAVEAISDRICIHTNAHVSVEVSAEDLLTCCGSMCGDGCNGGYPAEAWNFWTRKGLVSGGLYESHVGCRPYSIPPCEHHVNGSRPPCTGEGDTPKCSKICEPGYSPTYKQDKHYGYNSYSVSNSEKDIMAEIYKNGPVEGAFSVYSDFLLYKSGVYQHVTGEMMGGHAIRILGWGVENGTPYWLVANSWNTDWGDNGFFKILRGQDHCGIESEVVAGIPRTDQYWEKI
  
Inhibitor
Name:
BDBM50148310
Synonyms:
((S)-1-Formyl-pentyl)-carbamic acid (S)-1-benzyl-propyl ester | CHEMBL114462
Type:
Small organic molecule
Emp. Form.:
C17H25NO3
Mol. Mass.:
291.3853
SMILES:
CCCC[C@H](NC(=O)O[C@@H](CC)Cc1ccccc1)C=O
Structure:
Search PDB for entries with ligand similarity: