Reaction Details Report a problem with these data
Target
Transthyretin
Ligand
BDBM50197885
Substrate
n/a
Meas. Tech.
ChEMBL_2148790 (CHEMBL5033188)
IC50
160±n/a nM
Citation
 Cioffi, CL; Raja, A; Muthuraman, P; Jayaraman, A; Jayakumar, S; Varadi, A; Racz, B; Petrukhin, K Identification of Transthyretin Tetramer Kinetic Stabilizers That Are Capable of Inhibiting the Retinol-Dependent Retinol Binding Protein 4-Transthyretin Interaction: Potential Novel Therapeutics for Macular Degeneration, Transthyretin Amyloidosis, and Their Common Age-Related Comorbidities. J Med Chem 64:9010-9041 (2021) [PubMed]  Article 
Target
Name:
Transthyretin
Synonyms:
ATTR | PALB | Prealbumin | TBPA | TTHY_HUMAN | TTR | Transthyretin (TTR)
Type:
Enzyme
Mol. Mass.:
15884.31
Organism:
Homo sapiens (Human)
Description:
P02766
Residue:
147
Sequence:
MASHRLLLLCLAGLVFVSEAGPTGTGESKCPLMVKVLDAVRGSPAINVAVHVFRKAADDTWEPFASGKTSESGELHGLTTEEEFVEGIYKVEIDTKSYWKALGISPFHEHAEVVFTANDSGPRRYTIAALLSPYSYSTTAVVTNPKE
  
Inhibitor
Name:
BDBM50197885
Synonyms:
CHEMBL3940890
Type:
Small organic molecule
Emp. Form.:
C15H17FN2O3
Mol. Mass.:
292.3055
SMILES:
Cc1n[nH]c(C)c1CCCOc1cc(ccc1F)C(O)=O
Structure:
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