Reaction Details Report a problem with these data
Target
Melatonin receptor type 1B
Ligand
BDBM50149169
Substrate
n/a
Meas. Tech.
ChEBML_104938
EC50
0.740000±n/a nM
Citation
 Sun, LQ; Chen, J; Bruce, M; Deskus, JA; Epperson, JR; Takaki, K; Johnson, G; Iben, L; Mahle, CD; Ryan, E; Xu, C Synthesis and structure-activity relationship of novel benzoxazole derivatives as melatonin receptor agonists. Bioorg Med Chem Lett 14:3799-802 (2004) [PubMed]  Article 
Target
Name:
Melatonin receptor type 1B
Synonyms:
MTR1B_RAT | Melatonin receptor 1B | Mt2 | Mtnr1b
Type:
PROTEIN
Mol. Mass.:
40205.08
Organism:
Rattus norvegicus
Description:
ChEMBL_12487
Residue:
364
Sequence:
MPDNSSIANCCAASGLAARPSWPGSAEAEPPETPRAPWVAPMLSTVVIVTTAVDFVGNLLVILSVLRNRKLRNAGNLFVVNLALADLVVALYPYPLILVAILHDGWVLGEIHCKASAFVMGLSVIGSVFNITAIAINRYWCICHSATYHRACSQWHAPLYISLIWLLTLVALVPNFFVGSLEYDPRIYSCTFIQTASTQYTMAVVAIHFLLPIAVVSFCYLRIWILVLQARRKAKAERKLRLRPSDLRSFLTMFAVFVVFAICWAPLNCIGLAVAINPEAMALQIPEGLFVTSYFLAYFNSCLNAIVYGLLNQNFRREYKRILSALWSTGRCFHDASKCHLTEDLQGPVPPAAMATIPVQEGAL
  
Inhibitor
Name:
BDBM50149169
Synonyms:
CHEMBL127570 | Cyclopropanecarboxylic acid [3-(2-methyl-benzooxazol-7-yl)-propyl]-amide
Type:
Small organic molecule
Emp. Form.:
C15H18N2O2
Mol. Mass.:
258.3156
SMILES:
Cc1nc2cccc(CCCNC(=O)C3CC3)c2o1
Structure:
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