Reaction Details
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Small conductance calcium-activated potassium channel protein 2
Ligand
BDBM50583198
Substrate
n/a
Meas. Tech.
ChEMBL_2156785 (CHEMBL5041445)
EC50
>100000±n/a nM
Citation
El-Sayed, NS; Nam, YW; Egorova, PA; Nguyen, HM; Orfali, R; Rahman, MA; Yang, G; Wulff, H; Bezprozvanny, I; Parang, K; Zhang, M Structure-Activity Relationship Study of Subtype-Selective Positive Modulators of K J Med Chem 65:303-322 (2022) [PubMed] Article More Info.:
Target
Name:
Small conductance calcium-activated potassium channel protein 2
Synonyms:
KCNN2_RAT | Kcnn2 | Small conductance calcium-activated potassium channel | Small conductance calcium-activated potassium channel protein 2 | Small conductance calcium-activated potassium channel protein 2 (KCa2.2)
Type:
Protein
Mol. Mass.:
63876.72
Organism:
Rattus norvegicus (Rat)
Description:
P70604
Residue:
580
Sequence:
MSSCRYNGGVMRPLSNLSSSRRNLHEMDSEAQPLQPPASVVGGGGGASSPSAAAAASSSAPEIVVSKPEHNNSNNLALYGTGGGGSTGGGGGGGGGGGGSGHGSSSGTKSSKKKNQNIGYKLGHRRALFEKRKRLSDYALIFGMFGIVVMVIETELSWGAYDKASLYSLALKCLISLSTIILLGLIIVYHAREIQLFMVDNGADDWRIAMTYERIFFICLEILVCAIHPIPGNYTFTWTARLAFSYAPSTTTADVDIILSIPMFLRLYLIARVMLLHSKLFTDASSRSIGALNKINFNTRFVMKTLMTICPGTVLLVFSISLWIIAAWTVRACERYHDQQDVTSNFLGAMWLISITFLSIGYGDMVPNTYCGKGVCLLTGIMGAGCTALVVAVVARKLELTKAEKHVHNFMMDTQLTKRVKNAAANVLRETWLIYKNTKLVKKIDHAKVRKHQRKFLQAIHQLRSVKMEQRKLNDQANTLVDLAKTQNIMYDMISDLNERSEDFEKRIVTLETKLETLIGSIHALPGLISQTIRQQQRDFIETQMENYDKHVTYNAERSRSSSRRRRSSSTAPPTSSESS
Inhibitor
Name:
BDBM50583198
Synonyms:
CHEMBL5090455
Type:
Small organic molecule
Emp. Form.:
C17H25N5O
Mol. Mass.:
315.4133
SMILES:
Cc1cc(C)n(n1)-c1nc(C)cc(N[C@@H]2CC[C@H](CO)CC2)n1 |r,wD:14.14,17.18,(49.78,-10.62,;48.25,-10.79,;47.48,-12.12,;45.97,-11.8,;44.83,-12.83,;45.81,-10.27,;47.21,-9.64,;44.47,-9.51,;43.13,-10.28,;41.8,-9.51,;40.47,-10.28,;41.8,-7.96,;43.13,-7.19,;43.13,-5.65,;44.46,-4.88,;44.45,-3.34,;45.78,-2.57,;47.12,-3.33,;48.45,-2.56,;49.79,-3.32,;47.13,-4.87,;45.79,-5.65,;44.47,-7.96,)|
Structure:
