Reaction Details
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Small conductance calcium-activated potassium channel protein 2
Ligand
BDBM50583212
Substrate
n/a
Meas. Tech.
ChEMBL_2156785 (CHEMBL5041445)
EC50
1990±n/a nM
Citation
El-Sayed, NS; Nam, YW; Egorova, PA; Nguyen, HM; Orfali, R; Rahman, MA; Yang, G; Wulff, H; Bezprozvanny, I; Parang, K; Zhang, M Structure-Activity Relationship Study of Subtype-Selective Positive Modulators of K J Med Chem 65:303-322 (2022) [PubMed] Article More Info.:
Target
Name:
Small conductance calcium-activated potassium channel protein 2
Synonyms:
KCNN2_RAT | Kcnn2 | Small conductance calcium-activated potassium channel | Small conductance calcium-activated potassium channel protein 2 | Small conductance calcium-activated potassium channel protein 2 (KCa2.2)
Type:
Protein
Mol. Mass.:
63876.72
Organism:
Rattus norvegicus (Rat)
Description:
P70604
Residue:
580
Sequence:
MSSCRYNGGVMRPLSNLSSSRRNLHEMDSEAQPLQPPASVVGGGGGASSPSAAAAASSSAPEIVVSKPEHNNSNNLALYGTGGGGSTGGGGGGGGGGGGSGHGSSSGTKSSKKKNQNIGYKLGHRRALFEKRKRLSDYALIFGMFGIVVMVIETELSWGAYDKASLYSLALKCLISLSTIILLGLIIVYHAREIQLFMVDNGADDWRIAMTYERIFFICLEILVCAIHPIPGNYTFTWTARLAFSYAPSTTTADVDIILSIPMFLRLYLIARVMLLHSKLFTDASSRSIGALNKINFNTRFVMKTLMTICPGTVLLVFSISLWIIAAWTVRACERYHDQQDVTSNFLGAMWLISITFLSIGYGDMVPNTYCGKGVCLLTGIMGAGCTALVVAVVARKLELTKAEKHVHNFMMDTQLTKRVKNAAANVLRETWLIYKNTKLVKKIDHAKVRKHQRKFLQAIHQLRSVKMEQRKLNDQANTLVDLAKTQNIMYDMISDLNERSEDFEKRIVTLETKLETLIGSIHALPGLISQTIRQQQRDFIETQMENYDKHVTYNAERSRSSSRRRRSSSTAPPTSSESS
Inhibitor
Name:
BDBM50583212
Synonyms:
CHEMBL5076878
Type:
Small organic molecule
Emp. Form.:
C16H15ClFN5
Mol. Mass.:
331.775
SMILES:
Cc1cc(C)n(n1)-c1nc(C)cc(Nc2ccc(Cl)cc2F)n1
Structure:
