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Target
Tryptase beta-2
Ligand
BDBM50152193
Substrate
n/a
Meas. Tech.
ChEMBL_303103 (CHEMBL829613)
Ki
580±n/a nM
Citation
 Hopkins, C; Neuenschwander, K; Scotese, A; Jackson, S; Nieduzak, T; Pauls, H; Liang, G; Sides, K; Cramer, D; Cairns, J; Maignan, S; Mathieu, M Novel pyrazinone inhibitors of mast cell tryptase: synthesis and SAR evaluation. Bioorg Med Chem Lett 14:4819-23 (2004) [PubMed]  Article 
Target
Name:
Tryptase beta-2
Synonyms:
TPS2 | TPSB2 | TRYB2_HUMAN | Tryptase | Tryptase II | Tryptase beta-1 | Tryptase-2
Type:
PROTEIN
Mol. Mass.:
30518.79
Organism:
Homo sapiens (Human)
Description:
ChEMBL_210702
Residue:
275
Sequence:
MLNLLLLALPVLASRAYAAPAPGQALQRVGIVGGQEAPRSKWPWQVSLRVHGPYWMHFCGGSLIHPQWVLTAAHCVGPDVKDLAALRVQLREQHLYYQDQLLPVSRIIVHPQFYTAQIGADIALLELEEPVNVSSHVHTVTLPPASETFPPGMPCWVTGWGDVDNDERLPPPFPLKQVKVPIMENHICDAKYHLGAYTGDDVRIVRDDMLCAGNTRRDSCQGDSGGPLVCKVNGTWLQAGVVSWGEGCAQPNRPGIYTRVTYYLDWIHHYVPKKP
  
Inhibitor
Name:
BDBM50152193
Synonyms:
CHEMBL187649 | N-(3-Aminomethyl-phenyl)-2-{3-[(6-amino-2-methyl-pyridin-3-ylmethyl)-amino]-5-chloro-6-methyl-2-oxo-2H-pyrazin-1-yl}-acetamide; TFA
Type:
Small organic molecule
Emp. Form.:
C21H24ClN7O2
Mol. Mass.:
441.914
SMILES:
Cc1nc(N)ccc1CNc1nc(Cl)c(C)n(CC(=O)Nc2cccc(CN)c2)c1=O
Structure:
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