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Target
Melanin-concentrating hormone receptor 1
Ligand
BDBM50152494
Substrate
n/a
Meas. Tech.
ChEMBL_306738 (CHEMBL832325)
IC50
0.9±n/a nM
Citation
 Souers, AJ; Wodka, D; Gao, J; Lewis, JC; Vasudevan, A; Brodjian, S; Dayton, B; Ogiela, CA; Fry, D; Hernandez, LE; Marsh, KC; Collins, CA; Kym, PR Synthesis and evaluation of 2-amino-8-alkoxy quinolines as MCHr1 antagonists. Part 3. Bioorg Med Chem Lett 14:4883-6 (2004) [PubMed]  Article 
Target
Name:
Melanin-concentrating hormone receptor 1
Synonyms:
G-protein coupled receptor 24 | GPR24 | MCH receptor 1 | MCH-1R | MCH-R1 | MCHR | MCHR-1 | MCHR1 | MCHR1_HUMAN | Melanin Concentrating Hormone 1 | Melanin-Concentrating Hormone Receptor 1 (MCH1R) | Melanin-concentrating hormone receptor | Melanin-concentrating hormone receptor 1 (MCH-1) | Melanin-concentrating hormone receptor 1 (MCH1) | Melanin-concentrating hormone receptor 1 (MCHR-1) | Melanin-concentrating hormone receptor 1 (MCHR1) | SLC-1 | SLC1 | Somatostatin receptor-like protein
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
45976.27
Organism:
Homo sapiens (Human)
Description:
Membranes from CHO-K1 cells stably expressing human MCH1R were used in assays.
Residue:
422
Sequence:
MSVGAMKKGVGRAVGLGGGSGCQATEEDPLPNCGACAPGQGGRRWRLPQPAWVEGSSARLWEQATGTGWMDLEASLLPTGPNASNTSDGPDNLTSAGSPPRTGSISYINIIMPSVFGTICLLGIIGNSTVIFAVVKKSKLHWCNNVPDIFIINLSVVDLLFLLGMPFMIHQLMGNGVWHFGETMCTLITAMDANSQFTSTYILTAMAIDRYLATVHPISSTKFRKPSVATLVICLLWALSFISITPVWLYARLIPFPGGAVGCGIRLPNPDTDLYWFTLYQFFLAFALPFVVITAAYVRILQRMTSSVAPASQRSIRLRTKRVTRTAIAICLVFFVCWAPYYVLQLTQLSISRPTLTFVYLYNAAISLGYANSCLNPFVYIVLCETFRKRLVLSVKPAAQGQLRAVSNAQTADEERTESKGT
  
Inhibitor
Name:
BDBM50152494
Synonyms:
8-[1-(2,2-Difluoro-benzo[1,3]dioxol-5-yl)-pyrrolidin-3-yloxy]-quinolin-2-ylamine | CHEMBL181813
Type:
Small organic molecule
Emp. Form.:
C20H17F2N3O3
Mol. Mass.:
385.3641
SMILES:
Nc1ccc2cccc(OC3CCN(C3)c3ccc4OC(F)(F)Oc4c3)c2n1
Structure:
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