Reaction Details Report a problem with these data
Target
Growth hormone secretagogue receptor type 1
Ligand
BDBM50153550
Substrate
n/a
Meas. Tech.
ChEMBL_306821 (CHEMBL831012)
IC50
162±n/a nM
Citation
 Liu, B; Liu, G; Xin, Z; Serby, MD; Zhao, H; Schaefer, VG; Falls, HD; Kaszubska, W; Collins, CA; Sham, HL Novel isoxazole carboxamides as growth hormone secretagogue receptor (GHS-R) antagonists. Bioorg Med Chem Lett 14:5223-6 (2004) [PubMed]  Article 
Target
Name:
Growth hormone secretagogue receptor type 1
Synonyms:
GH-releasing peptide receptor | GHRP | GHS-R | GHSR | GHSR_HUMAN | Ghrelin Receptor (Growth Hormone Secretagogue Receptor Type 1) | Ghrelin receptor | Ghrelin receptor 1a (GHS-R1a)
Type:
Receptor
Mol. Mass.:
41334.57
Organism:
Homo sapiens (Human)
Description:
Receptor binding studies use plasma membranes from LLC PK-1 cells transiently transfected with hGHSR1a.
Residue:
366
Sequence:
MWNATPSEEPGFNLTLADLDWDASPGNDSLGDELLQLFPAPLLAGVTATCVALFVVGIAGNLLTMLVVSRFRELRTTTNLYLSSMAFSDLLIFLCMPLDLVRLWQYRPWNFGDLLCKLFQFVSESCTYATVLTITALSVERYFAICFPLRAKVVVTKGRVKLVIFVIWAVAFCSAGPIFVLVGVEHENGTDPWDTNECRPTEFAVRSGLLTVMVWVSSIFFFLPVFCLTVLYSLIGRKLWRRRRGDAVVGASLRDQNHKQTVKMLAVVVFAFILCWLPFHVGRYLFSKSFEPGSLEIAQISQYCNLVSFVLFYLSAAINPILYNIMSKKYRVAVFRLLGFEPFSQRKLSTLKDESSRAWTESSINT
  
Inhibitor
Name:
BDBM50153550
Synonyms:
5-(2-Benzo[1,3]dioxol-4-yl-ethyl)-3-(2,6-dichloro-phenyl)-isoxazole-4-carboxylic acid (4-diethylamino-phenyl)-amide | CHEMBL185028
Type:
Small organic molecule
Emp. Form.:
C29H27Cl2N3O4
Mol. Mass.:
552.448
SMILES:
CCN(CC)c1ccc(NC(=O)c2c(CCc3cccc4OCOc34)onc2-c2c(Cl)cccc2Cl)cc1 |(8.18,-4.11,;6.71,-3.64,;6.38,-2.15,;7.53,-1.1,;8.99,-1.58,;4.92,-1.68,;3.78,-2.71,;2.33,-2.24,;2,-.73,;.54,-.26,;-.61,-1.29,;-.28,-2.8,;-2.07,-.82,;-2.54,.64,;-1.65,1.88,;-2.28,3.29,;-1.37,4.54,;.16,4.37,;1.05,5.63,;.43,7.03,;-1.12,7.17,;-2.03,8.4,;-3.47,7.91,;-3.47,6.4,;-2,5.93,;-4.08,.63,;-4.56,-.82,;-3.32,-1.72,;-3.3,-3.26,;-4.63,-4.03,;-5.96,-3.26,;-4.63,-5.58,;-3.3,-6.34,;-1.96,-5.58,;-1.96,-4.03,;-.42,-4.03,;3.13,.3,;4.59,-.17,)|
Structure:
Search PDB for entries with ligand similarity: