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Target
Nociceptin receptor
Ligand
BDBM50153612
Substrate
n/a
Meas. Tech.
ChEMBL_303151 (CHEMBL829125)
Ki
>10000±n/a nM
Citation
 Chen, Z; Davies, E; Miller, WS; Shan, S; Valenzano, KJ; Kyle, DJ Design and synthesis of 4-phenyl piperidine compounds targeting the mu receptor. Bioorg Med Chem Lett 14:5275-9 (2004) [PubMed]  Article 
Target
Name:
Nociceptin receptor
Synonyms:
KOR-3 | Kappa-type 3 opioid receptor | Mu-type opioid receptor (Mu) | NOP | Nociceptin Receptor (ORL1 Receptor) | Nociceptin receptor (NOP) | Nociceptin receptor (ORL-1) | Nociceptin receptor (ORL1) | Nociceptin/Orphanin FQ, NOP receptor | OOR | OPIATE ORL-1 | OPRL1 | OPRL1 protein | OPRX_HUMAN | ORL1 | ORL1 receptor | Opioid receptor like-1 | Orphanin FQ receptor | Orphanin FQ receptor (ORL1) | P41146
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
40702.87
Organism:
Homo sapiens (Human)
Description:
P41146
Residue:
370
Sequence:
MEPLFPAPFWEVIYGSHLQGNLSLLSPNHSLLPPHLLLNASHGAFLPLGLKVTIVGLYLAVCVGGLLGNCLVMYVILRHTKMKTATNIYIFNLALADTLVLLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVRTSSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEEIECLVEIPTPQDYWGPVFAICIFLFSFIVPVLVISVCYSLMIRRLRGVRLLSGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLAQGLGVQPSSETAVAILRFCTALGYVNSCLNPILYAFLDENFKACFRKFCCASALRRDVQVSDRVRSIAKDVALACKTSETVPRPA
  
Inhibitor
Name:
BDBM50153612
Synonyms:
4-(4-Chloro-3-trifluoromethyl-phenyl)-1-naphthalen-2-ylmethyl-1-oxy-piperidin-4-ol | CHEMBL187083
Type:
Small organic molecule
Emp. Form.:
C23H21ClF3NO2
Mol. Mass.:
435.867
SMILES:
OC1(CC[N+]([O-])(Cc2ccc3ccccc3c2)CC1)c1ccc(Cl)c(c1)C(F)(F)F |(-1.02,2.26,;.31,1.49,;-1.02,.72,;-1.02,-.82,;.31,-1.59,;1.64,-2.36,;-.48,-2.92,;-2.02,-2.89,;-2.77,-1.55,;-4.31,-1.52,;-5.08,-2.85,;-6.62,-2.85,;-7.41,-4.18,;-6.64,-5.51,;-5.1,-5.53,;-4.33,-4.21,;-2.79,-4.21,;1.64,-.82,;1.64,.72,;1.41,2.58,;.99,4.08,;2.06,5.17,;3.58,4.8,;4.65,5.9,;3.97,3.29,;2.9,2.19,;5.49,2.91,;6.77,3.87,;6.84,2.56,;6.14,1.45,)|
Structure:
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