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Target
Calcium/calmodulin-dependent protein kinase type 1B
Ligand
BDBM50585045
Substrate
n/a
Meas. Tech.
ChEMBL_2161408 (CHEMBL5046158)
IC50
830±n/a nM
Citation
 Powell, CE; Hatcher, JM; Jiang, J; Vatsan, PS; Che, J; Gray, NS Selective Macrocyclic Inhibitors of DYRK1A/B. ACS Med Chem Lett 13:577-585 (2022) [PubMed]  Article 
Target
Name:
Calcium/calmodulin-dependent protein kinase type 1B
Synonyms:
CaM kinase I beta | CaM kinase IB | CaM-KI beta | CaMKI-beta | Calcium/calmodulin-dependent protein kinase type 1B | KCC1B_HUMAN | PNCK | Pregnancy up-regulated non-ubiquitously-expressed CaM kinase
Type:
PROTEIN
Mol. Mass.:
38501.47
Organism:
Homo sapiens (Human)
Description:
ChEMBL_109914
Residue:
343
Sequence:
MLLLKKHTEDISSVYEIRERLGSGAFSEVVLAQERGSAHLVALKCIPKKALRGKEALVENEIAVLRRISHPNIVALEDVHESPSHLYLAMELVTGGELFDRIMERGSYTEKDASHLVGQVLGAVSYLHSLGIVHRDLKPENLLYATPFEDSKIMVSDFGLSKIQAGNMLGTACGTPGYVAPELLEQKPYGKAVDVWALGVISYILLCGYPPFYDESDPELFSQILRASYEFDSPFWDDISESAKDFIRHLLERDPQKRFTCQQALRHLWISGDTAFDRDILGSVSEQIRKNFARTHWKRAFNATSFLRHIRKLGQIPEGEGASEQGMARHSHSGLRAGQPPKW
  
Inhibitor
Name:
BDBM50585045
Synonyms:
CHEMBL5093741
Type:
Small organic molecule
Emp. Form.:
C22H19F3N8O
Mol. Mass.:
468.4345
SMILES:
CN1Cc2nn(C)c(C#N)c2-c2cnc3[nH]cc(-c4cn(CCCC1=O)nc4C(F)(F)F)c3c2
Structure:
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