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Target
MAP/microtubule affinity-regulating kinase 4
Ligand
BDBM50516171
Substrate
n/a
Meas. Tech.
ChEMBL_2161727 (CHEMBL5046588)
IC50
>10000±n/a nM
Citation
 Drewry, DH; Annor-Gyamfi, JK; Wells, CI; Pickett, JE; Dederer, V; Preuss, F; Mathea, S; Axtman, AD Identification of Pyrimidine-Based Lead Compounds for Understudied Kinases Implicated in Driving Neurodegeneration. J Med Chem 65:1313-1328 (2022) [PubMed]  Article 
Target
Name:
MAP/microtubule affinity-regulating kinase 4
Synonyms:
KIAA1860 | MAP/microtubule affinity-regulating kinase 4 | MARK4 | MARK4_HUMAN | MARKL1
Type:
PROTEIN
Mol. Mass.:
82561.08
Organism:
Homo sapiens (Human)
Description:
ChEMBL_774620
Residue:
752
Sequence:
MSSRTVLAPGNDRNSDTHGTLGSGRSSDKGPSWSSRSLGARCRNSIASCPEEQPHVGNYRLLRTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPSSLQKLFREVRIMKGLNHPNIVKLFEVIETEKTLYLVMEYASAGEVFDYLVSHGRMKEKEARAKFRQIVSAVHYCHQKNIVHRDLKAENLLLDAEANIKIADFGFSNEFTLGSKLDTFCGSPPYAAPELFQGKKYDGPEVDIWSLGVILYTLVSGSLPFDGHNLKELRERVLRGKYRVPFYMSTDCESILRRFLVLNPAKRCTLEQIMKDKWINIGYEGEELKPYTEPEEDFGDTKRIEVMVGMGYTREEIKESLTSQKYNEVTATYLLLGRKTEEGGDRGAPGLALARVRAPSDTTNGTSSSKGTSHSKGQRSSSSTYHRQRRHSDFCGPSPAPLHPKRSPTSTGEAELKEERLPGRKASCSTAGSGSRGLPPSSPMVSSAHNPNKAEIPERRKDSTSTPNNLPPSMMTRRNTYVCTERPGAERPSLLPNGKENSSGTPRVPPASPSSHSLAPPSGERSRLARGSTIRSTFHGGQVRDRRAGGGGGGGVQNGPPASPTLAHEAAPLPAGRPRPTTNLFTKLTSKLTRRVADEPERIGGPEVTSCHLPWDQTETAPRLLRFPWSVKLTSSRPPEALMAALRQATAAARCRCRQPQPFLLACLHGGAGGPEPLSHFEVEVCQLPRPGLRGVLFRRVAGTALAFRTLVTRISNDLEL
  
Inhibitor
Name:
BDBM50516171
Synonyms:
CHEMBL4446892
Type:
Small organic molecule
Emp. Form.:
C17H17BrF3N7O2S
Mol. Mass.:
520.327
SMILES:
Cc1nn(CC(F)(F)F)cc1Nc1ncc(Br)c(NCc2ccc(cc2)S(N)(=O)=O)n1
Structure:
Search PDB for entries with ligand similarity: