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Target
Serine/threonine-protein kinase ULK3
Ligand
BDBM50585189
Substrate
n/a
Meas. Tech.
ChEMBL_2161745 (CHEMBL5046606)
IC50
1371±n/a nM
Citation
 Drewry, DH; Annor-Gyamfi, JK; Wells, CI; Pickett, JE; Dederer, V; Preuss, F; Mathea, S; Axtman, AD Identification of Pyrimidine-Based Lead Compounds for Understudied Kinases Implicated in Driving Neurodegeneration. J Med Chem 65:1313-1328 (2022) [PubMed]  Article 
Target
Name:
Serine/threonine-protein kinase ULK3
Synonyms:
ULK3 | ULK3_HUMAN
Type:
PROTEIN
Mol. Mass.:
53449.41
Organism:
Homo sapiens (Human)
Description:
ChEMBL_774298
Residue:
472
Sequence:
MAGPGWGPPRLDGFILTERLGSGTYATVYKAYAKKDTREVVAIKCVAKKSLNKASVENLLTEIEILKGIRHPHIVQLKDFQWDSDNIYLIMEFCAGGDLSRFIHTRRILPEKVARVFMQQLASALQFLHERNISHLDLKPQNILLSSLEKPHLKLADFGFAQHMSPWDEKHVLRGSPLYMAPEMVCQRQYDARVDLWSMGVILYEALFGQPPFASRSFSELEEKIRSNRVIELPLRPLLSRDCRDLLQRLLERDPSRRISFQDFFAHPWVDLEHMPSGESLGRATALVVQAVKKDQEGDSAAALSLYCKALDFFVPALHYEVDAQRKEAIKAKVGQYVSRAEELKAIVSSSNQALLRQGTSARDLLREMARDKPRLLAALEVASAAMAKEEAAGGEQDALDLYQHSLGELLLLLAAEPPGRRRELLHTEVQNLMARAEYLKEQVKMRESRWEADTLDKEGLSESVRSSCTLQ
  
Inhibitor
Name:
BDBM50585189
Synonyms:
CHEMBL5083125
Type:
Small organic molecule
Emp. Form.:
C22H25BrN6O3S
Mol. Mass.:
533.441
SMILES:
NS(=O)(=O)c1ccc(CNc2nc(Nc3cccc(CN4CCOCC4)c3)ncc2Br)cc1
Structure:
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