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Target
5-hydroxytryptamine receptor 6
Ligand
BDBM50585206
Substrate
n/a
Meas. Tech.
ChEMBL_2161777 (CHEMBL5046638)
Ki
4.7±n/a nM
Citation
 Marcinkowska, M; Bucki, A; Sniecikowska, J; Zagórska, A; Fajkis-Zaj?czkowska, N; Siwek, A; Gluch-Lutwin, M; ?mudzki, P; Jastrzebska-Wiesek, M; Partyka, A; Weso?owska, A; Abram, M; Przejczowska-Pomierny, K; Cios, A; Wyska, E; Mika, K; Kota?ska, M; Mierzejewski, P; Kolaczkowski, M Multifunctional Arylsulfone and Arylsulfonamide-Based Ligands with Prominent Mood-Modulating Activity and Benign Safety Profile, Targeting Neuropsychiatric Symptoms of Dementia. J Med Chem 64:12603-12629 (2021) [PubMed]  Article 
Target
Name:
5-hydroxytryptamine receptor 6
Synonyms:
5-HT-6 | 5-HT6 | 5-hydroxytryptamine receptor 6 (5-HT-6) | 5-hydroxytryptamine receptor 6 (5-HT6R) | 5-hydroxytryptamine receptor 6 (5HT6) | 5HT6R_HUMAN | HTR6 | Serotonin (5-HT3) receptor | Serotonin 6 (5-HT6) receptor | Serotonin Receptor 6
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
46968.43
Organism:
Homo sapiens (Human)
Description:
P50406
Residue:
440
Sequence:
MVPEPGPTANSTPAWGAGPPSAPGGSGWVAAALCVVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSASILNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFLPLLLGWHELGHARPPVPGQCRLLASLPFVLVASGLTFFLPSGAICFTYCRILLAARKQAVQVASLTTGMASQASETLQVPRTPRPGVESADSRRLATKHSRKALKASLTLGILLGMFFVTWLPFFVANIVQAVCDCISPGLFDVLTWLGYCNSTMNPIIYPLFMRDFKRALGRFLPCPRCPRERQASLASPSLRTSHSGPRPGLSLQQVLPLPLPPDSDSDSDAGSGGSSGLRLTAQLLLPGEATQDPPLPTRAAAAVNFFNIDPAEPELRPHPLGIPTN
  
Inhibitor
Name:
BDBM50585206
Synonyms:
CHEMBL5084167
Type:
Small organic molecule
Emp. Form.:
C25H25FN2O3S
Mol. Mass.:
452.541
SMILES:
Fc1ccc2c(CCCN3CCC(CS(=O)(=O)c4ccc5ccccc5c4)C3)noc2c1
Structure:
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