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Target
Mu-type opioid receptor
Ligand
BDBM50155124
Substrate
n/a
Meas. Tech.
ChEBML_302753
Ki
0.200000±n/a nM
Citation
 Coats, SJ; Schulz, MJ; Carson, JR; Codd, EE; Hlasta, DJ; Pitis, PM; Stone, DJ; Zhang, SP; Colburn, RW; Dax, SL Parallel methods for the preparation and SAR exploration of N-ethyl-4-[(8-alkyl-8-aza-bicyclo[3.2.1]oct-3-ylidene)-aryl-methyl]-benzamides, powerful mu and delta opioid agonists. Bioorg Med Chem Lett 14:5493-8 (2004) [PubMed]  Article 
Target
Name:
Mu-type opioid receptor
Synonyms:
M-OR-1 | MOR-1 | Mor | OPIATE Mu | OPRM_MOUSE | Opioid receptors; mu and delta | Oprm | Oprm1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
44431.62
Organism:
MOUSE
Description:
OPIATE Mu OPRM1 MOUSE::P42866
Residue:
398
Sequence:
MDSSAGPGNISDCSDPLAPASCSPAPGSWLNLSHVDGNQSDPCGPNRTGLGGSHSLCPQTGSPSMVTAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGNILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALITIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSTIEQQNSARIRQNTREHPSTANTVDRTNHQLENLEAETAPLP
  
Inhibitor
Name:
BDBM50155124
Synonyms:
4-{Bromo-[(1S,5R)-8-furan-3-ylmethyl-8-aza-bicyclo[3.2.1]oct-(3E)-ylidene]-methyl}-N-ethyl-benzamide | CHEMBL185980
Type:
Small organic molecule
Emp. Form.:
C22H25BrN2O2
Mol. Mass.:
429.35
SMILES:
CCNC(=O)c1ccc(cc1)C(\Br)=C1\C[C@@H]2CC[C@H](C1)N2Cc1ccoc1 |THB:21:20:13.14.19:17.16|
Structure:
Search PDB for entries with ligand similarity: