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Target
VIM-1 metallo-beta-lactamase
Ligand
BDBM50585852
Substrate
n/a
Meas. Tech.
ChEMBL_2164142 (CHEMBL5049003)
IC50
900±n/a nM
Citation
 Kaya, C; Konstantinovi?, J; Kany, AM; Andreas, A; Kramer, JS; Brunst, S; Weizel, L; Rotter, MJ; Frank, D; Yahiaoui, S; Müller, R; Hartmann, RW; Haupenthal, J; Proschak, E; Wichelhaus, TA; Hirsch, AKH -Aryl Mercaptopropionamides as Broad-Spectrum Inhibitors of Metallo-?-Lactamases. J Med Chem 65:3913-3922 (2022) [PubMed]  Article 
Target
Name:
VIM-1 metallo-beta-lactamase
Synonyms:
Beta-lactamase VIM-1 | VIM-1 | VIM-1 metallo-beta-lactamase | blaVIM-1
Type:
undefined
Mol. Mass.:
28014.53
Organism:
Klebsiella pneumoniae
Description:
Q5GN09
Residue:
266
Sequence:
MLKVISSLLVYMTASVMAVASPLAHSGEPSGEYPTVNEIPVGEVRLYQIADGVWSHIATQSFDGAVYPSNGLIVRDGDELLLIDTAWGAKNTAALLAEIEKQIGLPVTRAVSTHFHDDRVGGVDVLRAAGVATYASPSTRRLAEAEGNEIPTHSLEGLSSSGDAVRFGPVELFYPGAAHSTDNLVVYVPSANVLYGGCAVHELSSTSAGNVADADLAEWPTSVERIQKHYPEAEVVIPGHGLPGGLDLLQHTANVVKAHKNRSVAE
  
Inhibitor
Name:
BDBM50585852
Synonyms:
CHEMBL4790849
Type:
Small organic molecule
Emp. Form.:
C16H21NO3S
Mol. Mass.:
307.408
SMILES:
OC(=O)[C@H]1CCCCN1C(=O)C(CS)Cc1ccccc1 |r|
Structure:
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