Reaction Details Report a problem with these data
Target
5-hydroxytryptamine receptor 1A
Ligand
BDBM50155687
Substrate
n/a
Meas. Tech.
ChEMBL_303482 (CHEMBL838856)
Ki
15.2±n/a nM
Citation
 Bojarski, AJ; Duszynska, B; Kolaczkowski, M; Kowalski, P; Kowalska, T The impact of spacer structure on 5-HT7 and 5-HT1A receptor affinity in the group of long-chain arylpiperazine ligands. Bioorg Med Chem Lett 14:5863-6 (2004) [PubMed]  Article 
Target
Name:
5-hydroxytryptamine receptor 1A
Synonyms:
5-HT-1A | 5-HT1 | 5-HT1A | 5-Hydroxytryptamine receptor 1A (5-HT1A) | 5-hydroxytryptamine receptor 1A (5HT1A) | 5HT1A_RAT | 5ht1a | G-21 | Htr1a | Serotonin 1 (5-HT1) receptor | Serotonin 1a (5-HT1a) receptor/Adrenergic receptor alpha-1 | Serotonin receptor 1A
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
46445.29
Organism:
Rattus norvegicus (rat)
Description:
Binding assays were performed using rat hippocampal membranes.
Residue:
422
Sequence:
MDVFSFGQGNNTTASQEPFGTGGNVTSISDVTFSYQVITSLLLGTLIFCAVLGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCCTSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLISIPPMLGWRTPEDRSDPDACTISKDHGYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVRKVEKKGAGTSLGTSSAPPPKKSLNGQPGSGDWRRCAENRAVGTPCTNGAVRQGDDEATLEVIEVHRVGNSKEHLPLPSESGSNSYAPACLERKNERNAEAKRKMALARERKTVKTLGIIMGTFILCWLPFFIVALVLPFCESSCHMPALLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIKCKFCRR
  
Inhibitor
Name:
BDBM50155687
Synonyms:
1-{4-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-cyclohexyl}-pyrrolidine-2,5-dione | CHEMBL187270
Type:
Small organic molecule
Emp. Form.:
C21H29N3O3
Mol. Mass.:
371.4733
SMILES:
COc1ccccc1N1CCN(CC1)[C@H]1CC[C@@H](CC1)N1C(=O)CCC1=O |wU:14.15,wD:17.22,(-5.85,3.68,;-5.08,2.33,;-5.87,.97,;-7.41,.97,;-8.18,-.36,;-7.41,-1.69,;-5.87,-1.69,;-5.1,-.36,;-3.56,-.36,;-2.79,.97,;-1.23,.97,;-.46,-.36,;-1.23,-1.69,;-2.79,-1.69,;1.08,-.36,;1.87,.97,;3.39,.97,;4.18,-.36,;3.39,-1.69,;1.87,-1.69,;5.72,-.36,;6.05,1.16,;5.04,2.33,;7.57,1.32,;8.21,-.08,;7.05,-1.12,;7.19,-2.67,)|
Structure:
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