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Target
Thyrotropin-releasing hormone receptor
Ligand
BDBM50156179
Substrate
n/a
Meas. Tech.
ChEMBL_303571 (CHEMBL828971)
Ki
>10000±n/a nM
Citation
 Prokai, L; Prokai-Tatrai, K; Zharikova, AD; Nguyen, V; Perjesi, P; Stevens, SM Centrally acting and metabolically stable thyrotropin-releasing hormone analogues by replacement of histidine with substituted pyridinium. J Med Chem 47:6025-33 (2004) [PubMed]  Article 
Target
Name:
Thyrotropin-releasing hormone receptor
Synonyms:
TRH-R | TRHR_RAT | Thyroliberin receptor | Trhr
Type:
PROTEIN
Mol. Mass.:
46618.79
Organism:
Rattus norvegicus
Description:
ChEMBL_303571
Residue:
412
Sequence:
MENETVSELNQTELPPQVAVALEYQVVTILLVVVICGLGIVGNIMVVLVVMRTKHMRTATNCYLVSLAVADLMVLVAAGLPNITDSIYGSWVYGYVGCLCITYLQYLGINASSCSITAFTIERYIAICHPIKAQFLCTFSRAKKIIIFVWAFTSIYCMLWFFLLDLNISTYKDAIVISCGYKISRNYYSPIYLMDFGVFYVMPMILATVLYGFIARILFLNPIPSDPKENSKTWKNDSTHQNKNMNLNTTNRCFNSTVSSRKQVTKMLAVVVILFALLWMPYRTLVVVNSFLSSPFQENWFLLFCRICIYLNSAINPVIYNLMSQKFRAAFRKLCNCKQKPTEKAANYSVALNYSVIKESDRFSTELDDITVTDTYVSTTKVSFDDTCLASEKNGPSSCTYGYSLTAKQEKI
  
Inhibitor
Name:
BDBM50156179
Synonyms:
3-carbamoyl-1-{4-(2-carbamoyl-pyrrolidin-1-yl)-4-oxo-3-[(5-oxo-pyrrolidine-2-carbonyl)-amino]-butyl}-pyridinium; | CHEMBL362358
Type:
Small organic molecule
Emp. Form.:
C20H27N6O5
Mol. Mass.:
431.465
SMILES:
NC(=O)C1CCCN1C(=O)C(CC[n+]1cccc(c1)C(N)=O)NC(=O)C1CCC(=O)N1
Structure:
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