Reaction Details Report a problem with these data
Target
Adenosine receptor A1
Ligand
BDBM50157657
Substrate
n/a
Meas. Tech.
ChEMBL_430067 (CHEMBL918669)
Ki
2.1±n/a nM
Citation
 Chang, LC; Spanjersberg, RF; von Frijtag Drabbe Künzel, JK; Mulder-Krieger, T; van den Hout, G; Beukers, MW; Brussee, J; Ijzerman, AP 2,4,6-trisubstituted pyrimidines as a new class of selective adenosine A1 receptor antagonists. J Med Chem 47:6529-40 (2004) [PubMed]  Article 
Target
Name:
Adenosine receptor A1
Synonyms:
A1 adenosine receptor (hA1) | A1AR | AA1R_HUMAN | ADENOSINE A1 | ADORA1 | Adenosine A1 receptor (A1AR) | Adenosine A1-receptor | Adenosine receptor A1 (A1) | Adenosine receptor A1 (hA1) | Adenosine transporter (AdT)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
36520.92
Organism:
Homo sapiens (Human)
Description:
P30542
Residue:
326
Sequence:
MPPSISAFQAAYIGIEVLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAILINIGPQTYFHTCLMVACPVLILTQSSILALLAIAVDRYLRVKIPLRYKMVVTPRRAAVAIAGCWILSFVVGLTPMFGWNNLSAVERAWAANGSMGEPVIKCEFEKVISMEYMVYFNFFVWVLPPLLLMVLIYLEVFYLIRKQLNKKVSASSGDPQKYYGKELKIAKSLALILFLFALSWLPLHILNCITLFCPSCHKPSILTYIAIFLTHGNSAMNPIVYAFRIQKFRVTFLKIWNDHFRCQPAPPIDEDLPEERPDD
  
Inhibitor
Name:
BDBM50157657
Synonyms:
CHEMBL375631 | cyclopentanecarboxylic acid (2,6-diphenylpyrimidin-4-yl)amide
Type:
Small organic molecule
Emp. Form.:
C22H21N3O
Mol. Mass.:
343.4216
SMILES:
O=C(Nc1cc(nc(n1)-c1ccccc1)-c1ccccc1)C1CCCC1
Structure:
Search PDB for entries with ligand similarity: