Reaction Details Report a problem with these data
Target
Translocator protein
Ligand
BDBM50159083
Substrate
n/a
Meas. Tech.
ChEMBL_303739 (CHEMBL829782)
Ki
164±n/a nM
Citation
 Trapani, G; Laquintana, V; Denora, N; Trapani, A; Lopedota, A; Latrofa, A; Franco, M; Serra, M; Pisu, MG; Floris, I; Sanna, E; Biggio, G; Liso, G Structure-activity relationships and effects on neuroactive steroid synthesis in a series of 2-phenylimidazo[1,2-a]pyridineacetamide peripheral benzodiazepine receptors ligands. J Med Chem 48:292-305 (2005) [PubMed]  Article 
Target
Name:
Translocator protein
Synonyms:
Benzodiazepine receptors; peripheral & central | Bzrp | Mbr | Mitochondrial benzodiazepine receptor | PBR | PKBS | Peripheral benzodiazepine receptor (PBR) | Peripheral-Type Benzodiazepine Receptor | TSPO_RAT | Tspo
Type:
Mitochondrion membrane protein
Mol. Mass.:
18945.84
Organism:
Rattus norvegicus (rat)
Description:
Competitive binding experiments were performed on rat kidney mitochondrial membranes.
Residue:
169
Sequence:
MSQSWVPAVGLTLVPSLGGFMGAYFVRGEGLRWYASLQKPSWHPPRWTLAPIWGTLYSAMGYGSYIIWKELGGFTEEAMVPLGLYTGQLALNWAWPPIFFGARQMGWALVDLMLVSGVATATTLAWHRVSPPAARLLYPYLAWLAFATMLNYYVWRDNSGRRGGSRLTE
  
Inhibitor
Name:
BDBM50159083
Synonyms:
2-(6,8-Dichloro-2-phenyl-imidazo[1,2-a]pyridin-3-yl)-1-(3,4-dihydro-1H-isoquinolin-2-yl)-ethanone | 2-[6,8-Dichloro-2-(4-chloro-phenyl)-imidazo[1,2-a]pyridin-3-yl]-1-(3,4-dihydro-1H-isoquinolin-2-yl)-ethanone | CHEMBL369327
Type:
Small organic molecule
Emp. Form.:
C24H19Cl2N3O
Mol. Mass.:
436.333
SMILES:
Clc1cc(Cl)c2nc(c(CC(=O)N3CCc4ccccc4C3)n2c1)-c1ccccc1
Structure:
Search PDB for entries with ligand similarity: