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Target
Potassium channel subfamily K member 3
Ligand
BDBM50417943
Substrate
n/a
Meas. Tech.
ChEMBL_2188418 (CHEMBL5100500)
IC50
600±n/a nM
Citation
 Arévalo, B; Bedoya, M; Kiper, AK; Vergara, F; Ramírez, D; Mazola, Y; Bustos, D; Zúńiga, R; Cikutovic, R; Cayo, A; Rinné, S; Ramirez-Apan, MT; Sepúlveda, FV; Cerda, O; López-Collazo, E; Decher, N; Zúńiga, L; Gutierrez, M; González, W Selective TASK-1 Inhibitor with a Defined Structure-Activity Relationship Reduces Cancer Cell Proliferation and Viability. J Med Chem 65:15014-15027 (2022) [PubMed] 
Target
Name:
Potassium channel subfamily K member 3
Synonyms:
Acid-sensitive potassium channel TASK-1 | Acid-sensitive potassium channel protein TASK-1 | KCNK3 | KCNK3_HUMAN | Potassium channel protein TASK-1 | Potassium channel subfamily K member 3 | Potassium channel subfamily K member 3 (TASK-1) | TASK | TASK1 | TWIK-related acid-sensitive K(+) channel 1 | Two pore K(+) channel KT3.1 | Two pore potassium channel KT3.1
Type:
Protein
Mol. Mass.:
43534.71
Organism:
Homo sapiens (Human)
Description:
O14649
Residue:
394
Sequence:
MKRQNVRTLALIVCTFTYLLVGAAVFDALESEPELIERQRLELRQQELRARYNLSQGGYEELERVVLRLKPHKAGVQWRFAGSFYFAITVITTIGYGHAAPSTDGGKVFCMFYALLGIPLTLVMFQSLGERINTLVRYLLHRAKKGLGMRRADVSMANMVLIGFFSCISTLCIGAAAFSHYEHWTFFQAYYYCFITLTTIGFGDYVALQKDQALQTQPQYVAFSFVYILTGLTVIGAFLNLVVLRFMTMNAEDEKRDAEHRALLTRNGQAGGGGGGGSAHTTDTASSTAAAGGGGFRNVYAEVLHFQSMCSCLWYKSREKLQYSIPMIIPRDLSTSDTCVEQSHSSPGGGGRYSDTPSRRCLCSGAPRSAISSVSTGLHSLSTFRGLMKRRSSV
  
Inhibitor
Name:
BDBM50417943
Synonyms:
CHEMBL1671897
Type:
Small organic molecule
Emp. Form.:
C30H29N3O3
Mol. Mass.:
479.5696
SMILES:
COc1ccc(CC(=O)NCc2ccccc2-c2ccccc2C(=O)NCCc2cccnc2)cc1
Structure:
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