Reaction Details Report a problem with these data
Target
D(1A) dopamine receptor
Ligand
BDBM435739
Substrate
n/a
Meas. Tech.
ChEMBL_2192370 (CHEMBL5104730)
EC50
12±n/a nM
Citation
 Hao, J; Beck, J; Zhou, X; Lackner, GL; Johnston, R; Reinhard, M; Goldsmith, P; Hollinshead, S; Dehlinger, V; Filla, SA; Wang, XS; Richardson, J; Posada, M; Mohutsky, M; Schober, D; Katner, JS; Chen, Q; Hu, B; Remick, DM; Coates, DA; Mathes, BM; Hawk, MK; Svensson, KA; Hembre, E Synthesis and Preclinical Characterization of LY3154885, a Human Dopamine D1 Receptor Positive Allosteric Modulator with an Improved Nonclinical Drug-Drug Interaction Risk Profile. J Med Chem 65:3786-3797 (2022) [PubMed] 
Target
Name:
D(1A) dopamine receptor
Synonyms:
DA D1 receptor | DOPAMINE D1 | DRD1 | DRD1_HUMAN | Dopamine D1 receptor | Dopamine D1 receptor (D1R) | Dopamine D1A
Type:
Enzyme
Mol. Mass.:
49303.43
Organism:
Homo sapiens (Human)
Description:
P21728
Residue:
446
Sequence:
MRTLNTSAMDGTGLVVERDFSVRILTACFLSLLILSTLLGNTLVCAAVIRFRHLRSKVTNFFVISLAVSDLLVAVLVMPWKAVAEIAGFWPFGSFCNIWVAFDIMCSTASILNLCVISVDRYWAISSPFRYERKMTPKAAFILISVAWTLSVLISFIPVQLSWHKAKPTSPSDGNATSLAETIDNCDSSLSRTYAISSSVISFYIPVAIMIVTYTRIYRIAQKQIRRIAALERAAVHAKNCQTTTGNGKPVECSQPESSFKMSFKRETKVLKTLSVIMGVFVCCWLPFFILNCILPFCGSGETQPFCIDSNTFDVFVWFGWANSSLNPIIYAFNADFRKAFSTLLGCYRLCPATNNAIETVSINNNGAAMFSSHHEPRGSISKECNLVYLIPHAVGSSEDLKKEEAAGIARPLEKLSPALSVILDYDTDVSLEKIQPITQNGQHPT
  
Inhibitor
Name:
BDBM435739
Synonyms:
2-(2,6-dichlorophenyl)-1-((1S,3R)-3-(hydroxymethyl)-1-methyl-5-(1-methyl-1H-pyrazol-4-yl)-3,4-dihydroisoquinolin-2(1H)-yl)ethan-1-one | US10611751, Example 1
Type:
Small organic molecule
Emp. Form.:
C23H23Cl2N3O2
Mol. Mass.:
444.354
SMILES:
C[C@@H]1N([C@@H](CO)Cc2c1cccc2-c1cnn(C)c1)C(=O)Cc1c(Cl)cccc1Cl |r|
Structure:
Search PDB for entries with ligand similarity: