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Target
Casein kinase II subunit alpha
Ligand
BDBM50590135
Substrate
n/a
Meas. Tech.
ChEMBL_2195145 (CHEMBL5107505)
IC50
16000±n/a nM
Citation
 Brear, P; De Fusco, C; Atkinson, EL; Iegre, J; Francis-Newton, NJ; Venkitaraman, AR; Hyvönen, M; Spring, DR A fragment-based approach leading to the discovery of inhibitors of CK2? with a novel mechanism of action. RSC Med Chem 13:1420-1426 (2022) [PubMed] 
Target
Name:
Casein kinase II subunit alpha
Synonyms:
CK II | CK2 | CK2- alpha | CK2A1 | CSK21_HUMAN | CSNK2A1 | Casein kinase 2 | Casein kinase II (CK2) | Casein kinase II alpha/beta | Casein kinase II subunit alpha (CK2 alpha) | Casein kinase II subunit alpha (CK2A1) | Casein kinase II subunit alpha (CK2a I174A) | Casein kinase II subunit alpha (CK2a V66A) | Casein kinase II subunit alpha (CK2a dm V66I174AA) | Casein kinase II subunit alpha (CK2a)
Type:
Enzyme
Mol. Mass.:
45151.12
Organism:
Homo sapiens (Human)
Description:
P68400
Residue:
391
Sequence:
MSGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVKDQARMGSSSMPGGSTPVSSANMMSGISSVPTPSPLGPLAGSPVIAAANPLGMPVPAAAGAQQ
  
Inhibitor
Name:
BDBM50590135
Synonyms:
CHEMBL5180822
Type:
Small organic molecule
Emp. Form.:
C9H6BrN3
Mol. Mass.:
236.068
SMILES:
Brc1ccc2[nH]nc(CC#N)c2c1
Structure:
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