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Target
Elastase
Ligand
BDBM50590265
Substrate
n/a
Meas. Tech.
ChEMBL_2195751 (CHEMBL5108267)
IC50
16000±n/a nM
Citation
 Yahiaoui, S; Voos, K; Haupenthal, J; Wichelhaus, TA; Frank, D; Weizel, L; Rotter, M; Brunst, S; Kramer, JS; Proschak, E; Ducho, C; Hirsch, AKH -Aryl mercaptoacetamides as potential multi-target inhibitors of metallo-?-lactamases (MBLs) and the virulence factor LasB from  RSC Med Chem 12:1698-1708 (2021) [PubMed] 
Target
Name:
Elastase
Synonyms:
ELAS_PSEAE | Pseudolysin | lasB
Type:
PROTEIN
Mol. Mass.:
53687.94
Organism:
Pseudomonas aeruginosa
Description:
ChEMBL_619859
Residue:
498
Sequence:
MKKVSTLDLLFVAIMGVSPAAFAADLIDVSKLPSKAAQGAPGPVTLQAAVGAGGADELKAIRSTTLPNGKQVTRYEQFHNGVRVVGEAITEVKGPGKSVAAQRSGHFVANIAADLPGSTTAAVSAEQVLAQAKSLKAQGRKTENDKVELVIRLGENNIAQLVYNVSYLIPGEGLSRPHFVIDAKTGEVLDQWEGLAHAEAGGPGGNQKIGKYTYGSDYGPLIVNDRCEMDDGNVITVDMNSSTDDSKTTPFRFACPTNTYKQVNGAYSPLNDAHFFGGVVFKLYRDWFGTSPLTHKLYMKVHYGRSVENAYWDGTAMLFGDGATMFYPLVSLDVAAHEVSHGFTEQNSGLIYRGQSGGMNEAFSDMAGEAAEFYMRGKNDFLIGYDIKKGSGALRYMDQPSRDGRSIDNASQYYNGIDVHHSSGVYNRAFYLLANSPGWDTRKAFEVFVDANRYYWTATSNYNSGACGVIRSAQNRNYSAADVTRAFSTVGVTCPSAL
  
Inhibitor
Name:
BDBM50590265
Synonyms:
CHEMBL1330520
Type:
Small organic molecule
Emp. Form.:
C9H9ClN2O2S
Mol. Mass.:
244.698
SMILES:
NC(=O)SCC(=O)Nc1ccc(Cl)cc1
Structure:
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