Reaction Details Report a problem with these data
Target
N-acetyltransferase Eis
Ligand
BDBM50590304
Substrate
n/a
Meas. Tech.
ChEMBL_2195999 (CHEMBL5108515)
IC50
14000±n/a nM
Citation
 Punetha, A; Green, KD; Garzan, A; Thamban Chandrika, N; Willby, MJ; Pang, AH; Hou, C; Holbrook, SYL; Krieger, K; Posey, JE; Parish, T; Tsodikov, OV; Garneau-Tsodikova, S Structure-based design of haloperidol analogues as inhibitors of acetyltransferase Eis from  RSC Med Chem 12:1894-1909 (2021) [PubMed] 
Target
Name:
N-acetyltransferase Eis
Synonyms:
Aminoglycoside N-acetyltransferase | EIS_MYCTU | Enhanced intracellular survival protein | N-acetyltransferase Eis | Protein-lysine N-acetyltransferase | eis
Type:
PROTEIN
Mol. Mass.:
43803.37
Organism:
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Description:
ChEMBL_116995
Residue:
402
Sequence:
MTVTLCSPTEDDWPGMFLLAAASFTDFIGPESATAWRTLVPTDGAVVVRDGAGPGSEVVGMALYMDLRLTVPGEVVLPTAGLSFVAVAPTHRRRGLLRAMCAELHRRIADSGYPVAALHASEGGIYGRFGYGPATTLHELTVDRRFARFHADAPGGGLGGSSVRLVRPTEHRGEFEAIYERWRQQVPGGLLRPQVLWDELLAECKAAPGGDRESFALLHPDGYALYRVDRTDLKLARVSELRAVTADAHCALWRALIGLDSMERISIITHPQDPLPHLLTDTRLARTTWRQDGLWLRIMNVPAALEARGYAHEVGEFSTVLEVSDGGRFALKIGDGRARCTPTDAAAEIEMDRDVLGSLYLGAHRASTLAAANRLRTKDSQLLRRLDAAFASDVPVQTAFEF
  
Inhibitor
Name:
BDBM50590304
Synonyms:
CHEMBL5186626
Type:
Small organic molecule
Emp. Form.:
C20H24FNO
Mol. Mass.:
313.4091
SMILES:
Fc1ccc(OCCCN2CCC(CC2)c2ccccc2)cc1
Structure:
Search PDB for entries with ligand similarity: