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Target
Mu-type opioid receptor
Ligand
BDBM50590365
Substrate
n/a
Meas. Tech.
ChEMBL_2196369 (CHEMBL5108885)
IC50
5.1±n/a nM
Citation
 Kassick, AJ; Treat, A; Tomycz, N; Feasel, MG; Kolber, BJ; Averick, S Design, synthesis, and biological evaluation of C RSC Med Chem 13:175-182 (2022) [PubMed] 
Target
Name:
Mu-type opioid receptor
Synonyms:
M-OR-1 | MOP | MOR-1 | MOR1 | MUOR1 | Mu Opioid Receptor | Mu opiate receptor | OPIATE Mu | OPRM1 | OPRM_HUMAN | hMOP | mu-type opioid receptor isoform MOR-1
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
44789.51
Organism:
Homo sapiens (Human)
Description:
P35372
Residue:
400
Sequence:
MDSSAAPTNASNCTDALAYSSCSPAPSPGSWVNLSHLDGNLSDPCGPNRTDLGGRDSLCPPTGSPSMITAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALVTIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSNIEQQNSTRIRQNTRDHPSTANTVDRTNHQLENLEAETAPLP
  
Inhibitor
Name:
BDBM50590365
Synonyms:
CHEMBL5197033
Type:
Small organic molecule
Emp. Form.:
C21H23F2NO3
Mol. Mass.:
375.409
SMILES:
[H][C@@]12[#8]-c3c4c(-[#6][C@@]5([H])[#7](-[#6]-[#6]-6-[#6]-[#6]-6)-[#6]-[#6][C@@]14[C@@]5([#8])[#6]-[#6]\[#6]2=[#6](/F)F)ccc3-[#8] |r,THB:10:9:17:6.5.4|
Structure:
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