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Target
RNA-directed RNA polymerase
Ligand
BDBM50162611
Substrate
n/a
Meas. Tech.
ChEMBL_306582 (CHEMBL832929)
IC50
58±n/a nM
Citation
Pratt, JK; Donner, P; McDaniel, KF; Maring, CJ; Kati, WM; Mo, H; Middleton, T; Liu, Y; Ng, T; Xie, Q; Zhang, R; Montgomery, D; Molla, A; Kempf, DJ; Kohlbrenner, W Inhibitors of HCV NS5B polymerase: synthesis and structure-activity relationships of N-1-heteroalkyl-4-hydroxyquinolon-3-yl-benzothiadiazines. Bioorg Med Chem Lett 15:1577-82 (2005) [PubMed] Article
More Info.:
Target
Name:
RNA-directed RNA polymerase
Synonyms:
Hepatitis C virus NS5B RNA-dependent RNA polymerase | NS5B protein
Type:
Protein
Mol. Mass.:
25173.95
Organism:
Hepatitis C virus
Description:
Q8JXU8
Residue:
229
Sequence:
RTEEAIYQCCDLDPQARVAIRSLTERLYVGGPLTNSRGENCGYRRRASGVLTTSCGNTLTCYIKAQAACRAAGRQDCTMLVCGDDLVVICESAGVQEDAASLRAFTEAMTRYSAPPGDPPQPEYDLELITSCSSNVSVAHDGAGKRVYYLTRDPTTPLARAAWETARHTPVNSWLGNIIMFAPTLWVRMIMLTHFFSVLIARDQLEQALDCEIYGACYSIEPLLPPIIQ
Inhibitor
Name:
BDBM50162611
Synonyms:
3-(1,1-Dioxo-1,4-dihydro-1lambda*6*-benzo[1,2,4]thiadiazin-3-yl)-1-(2-ethyl-butyl)-4-hydroxy-1H-[1,8]naphthyridin-2-one | CHEMBL180772
Type:
Small organic molecule
Emp. Form.:
C21H22N4O4S
Mol. Mass.:
426.489
SMILES:
CCC(CC)Cn1c2ncccc2c(O)c(C2=NS(=O)(=O)c3ccccc3N2)c1=O |t:17|