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Target
Coagulation factor XIII A chain
Ligand
BDBM50164220
Substrate
n/a
Meas. Tech.
ChEMBL_304794 (CHEMBL877318)
IC50
>100000±n/a nM
Citation
 Leung-Toung, R; Tam, TF; Wodzinska, JM; Zhao, Y; Lowrie, J; Simpson, CD; Karimian, K; Spino, M 3-Substituted imidazo[1,2-d][1,2,4]-thiadiazoles: a novel class of factor XIIIa inhibitors. J Med Chem 48:2266-9 (2005) [PubMed]  Article 
Target
Name:
Coagulation factor XIII A chain
Synonyms:
Coagulation factor XIII | F13A | F13A1 | F13A_HUMAN
Type:
PROTEIN
Mol. Mass.:
83261.29
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1475048
Residue:
732
Sequence:
MSETSRTAFGGRRAVPPNNSNAAEDDLPTVELQGVVPRGVNLQEFLNVTSVHLFKERWDTNKVDHHTDKYENNKLIVRRGQSFYVQIDFSRPYDPRRDLFRVEYVIGRYPQENKGTYIPVPIVSELQSGKWGAKIVMREDRSVRLSIQSSPKCIVGKFRMYVAVWTPYGVLRTSRNPETDTYILFNPWCEDDAVYLDNEKEREEYVLNDIGVIFYGEVNDIKTRSWSYGQFEDGILDTCLYVMDRAQMDLSGRGNPIKVSRVGSAMVNAKDDEGVLVGSWDNIYAYGVPPSAWTGSVDILLEYRSSENPVRYGQCWVFAGVFNTFLRCLGIPARIVTNYFSAHDNDANLQMDIFLEEDGNVNSKLTKDSVWNYHCWNEAWMTRPDLPVGFGGWQAVDSTPQENSDGMYRCGPASVQAIKHGHVCFQFDAPFVFAEVNSDLIYITAKKDGTHVVENVDATHIGKLIVTKQIGGDGMMDITDTYKFQEGQEEERLALETALMYGAKKPLNTEGVMKSRSNVDMDFEVENAVLGKDFKLSITFRNNSHNRYTITAYLSANITFYTGVPKAEFKKETFDVTLEPLSFKKEAVLIQAGEYMGQLLEQASLHFFVTARINETRDVLAKQKSTVLTIPEIIIKVRGTQVVGSDMTVTVQFTNPLKETLRNVWVHLDGPGVTRPMKKMFREIRPNSTVQWEEVCRPWVSGHRKLIASMSSDSLRHVYGELDVQIQRRPSM
  
Inhibitor
Name:
BDBM50164220
Synonyms:
CHEMBL192376 | N-Hexyl-2-nitro-benzenesulfonamide
Type:
Small organic molecule
Emp. Form.:
C12H18N2O4S
Mol. Mass.:
286.347
SMILES:
CCCCCCNS(=O)(=O)c1ccccc1[N+]([O-])=O
Structure:
Search PDB for entries with ligand similarity: