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Target
Reverse transcriptase/RNaseH
Ligand
BDBM33411
Substrate
n/a
Meas. Tech.
ChEMBL_2204627 (CHEMBL5117335)
IC50
1980±n/a nM
Citation
 Zhang, L; Wei, F; Borrego, D; Zhao, F; Río, JMD; Frutos-Beltrán, E; Zhang, J; Xu, S; López-Carrobles, N; Gao, S; Kang, D; Pannecouque, C; Clercq, E; Liu, X; Menéndez-Arias, L; Zhan, P Design, synthesis, and biological evaluation of novel double-winged galloyl derivatives as HIV-1 RNase H inhibitors. Eur J Med Chem 240:0 (2022) [PubMed] 
Target
Name:
Reverse transcriptase/RNaseH
Synonyms:
HIV-1 Reverse Transcriptase RNase H | Human immunodeficiency virus type 1 reverse transcriptase | Reverse transcriptase/RNaseH
Type:
PROTEIN
Mol. Mass.:
65229.15
Organism:
Human immunodeficiency virus 1
Description:
ChEMBL_1473730
Residue:
566
Sequence:
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPVFAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKRKSVTVLDVGDAYFSVPLDEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVIYQYMDDLYVGSDLEIGQHRTKIEELRQHLLRWGLTTPDKKHQKEPPFLWMGYELHPDKWTVQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIRVRQLCKLLRGTKALTEVIPLTEEAELELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLRTGKYARMRGAHTNDVKQLTEAVQKITTESIVIWGKTPKFKLPIQKETWETWWTEYWQATWIPEWEFVNTPPLVKLWYQLEKEPIVGAETFYVDGAANRETKLGKAGYVTNRGRQKVVTLTDTTNQKTELQAIYLALQDSGLEVNIVTDSQYALGIIQAQPDQSESELVNQIIEQLIKKEKVYLAWVPAHKGIGGNEQVDKLVSAGIRKVLFLDGID
  
Inhibitor
Name:
BDBM33411
Synonyms:
β-Thujaplicinol | hydroxytropolone, 3
Type:
Small organic molecule
Emp. Form.:
C10H12O3
Mol. Mass.:
180.2005
SMILES:
CC(C)c1ccc(O)c(=O)c(O)c1
Structure:
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