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Target
B1 bradykinin receptor
Ligand
BDBM50410175
Substrate
n/a
Meas. Tech.
ChEMBL_302988 (CHEMBL830227)
Ki
1.8±n/a nM
Citation
 Feng, DM; Wai, JM; Kuduk, SD; Ng, C; Murphy, KL; Ransom, RW; Reiss, D; Chang, RS; Harrell, CM; MacNeil, T; Tang, C; Prueksaritanont, T; Freidinger, RM; Pettibone, DJ; Bock, MG 2,3-Diaminopyridine as a platform for designing structurally unique nonpeptide bradykinin B1 receptor antagonists. Bioorg Med Chem Lett 15:2385-8 (2005) [PubMed]  Article 
Target
Name:
B1 bradykinin receptor
Synonyms:
B1 BRADYKININ | B1 bradykinin receptor | B1R | BDKRB1 | BK-1 receptor | BKRB1_HUMAN | BRADYB1 | Bradykinin B1 receptor
Type:
Enzyme
Mol. Mass.:
40508.87
Organism:
Homo sapiens (Human)
Description:
P46663
Residue:
353
Sequence:
MASSWPPLELQSSNQSQLFPQNATACDNAPEAWDLLHRVLPTFIISICFFGLLGNLFVLLVFLLPRRQLNVAEIYLANLAASDLVFVLGLPFWAENIWNQFNWPFGALLCRVINGVIKANLFISIFLVVAISQDRYRVLVHPMASRRQQRRRQARVTCVLIWVVGGLLSIPTFLLRSIQAVPDLNITACILLLPHEAWHFARIVELNILGFLLPLAAIVFFNYHILASLRTREEVSRTRCGGRKDSKTTALILTLVVAFLVCWAPYHFFAFLEFLFQVQAVRGCFWEDFIDLGLQLANFFAFTNSSLNPVIYVFVGRLFRTKVWELYKQCTPKSLAPISSSHRKEIFQLFWRN
  
Inhibitor
Name:
BDBM50410175
Synonyms:
CHEMBL2113087
Type:
Small organic molecule
Emp. Form.:
C25H24F3N3O3
Mol. Mass.:
471.4716
SMILES:
COC(=O)c1ccccc1-c1ccc(cc1)[C@@H](C)Nc1nccc(C)c1NC(=O)CC(F)(F)F
Structure:
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