Reaction Details Report a problem with these data
Target
Mu-type opioid receptor
Ligand
BDBM50166018
Substrate
n/a
Meas. Tech.
ChEMBL_302475 (CHEMBL827167)
Ki
3100±n/a nM
Citation
 Grieco, P; Giusti, L; Carotenuto, A; Campiglia, P; Calderone, V; Lama, T; Gomez-Monterrey, I; Tartaro, G; Mazzoni, MR; Novellino, E Morphiceptin analogues containing a dipeptide mimetic structure: an investigation on the bioactive topology at the mu-receptor. J Med Chem 48:3153-63 (2005) [PubMed]  Article 
Target
Name:
Mu-type opioid receptor
Synonyms:
MOR-1 | MUOR1 | Mu-type opioid receptor (MOR) | OPIATE Mu | OPRM_RAT | Opiate non-selective | Opioid receptor B | Oprm1 | Ror-b
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
44503.11
Organism:
Rattus norvegicus (rat)
Description:
Competition binding assays were carried out using membrane preparations from transfected HN9.10 cells that constitutively expressed the mu opioid receptor.
Residue:
398
Sequence:
MDSSTGPGNTSDCSDPLAQASCSPAPGSWLNLSHVDGNQSDPCGLNRTGLGGNDSLCPQTGSPSMVTAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALITIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSTIEQQNSTRVRQNTREHPSTANTVDRTNHQLENLEAETAPLP
  
Inhibitor
Name:
BDBM50166018
Synonyms:
2-[(R)-1-Amino-2-((S)-4-hydroxy-phenyl)-ethyl]-thiazolidine-4-carboxylic acid [(S)-1-benzyl-2-((S)-2-carbamoyl-pyrrolidin-1-yl)-2-oxo-ethyl]-amide | CHEMBL191742
Type:
Small organic molecule
Emp. Form.:
C26H33N5O4S
Mol. Mass.:
511.636
SMILES:
N[C@@H](Cc1ccc(O)cc1)C1N[C@@H](CS1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(N)=O
Structure:
Search PDB for entries with ligand similarity: