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Target
Tyrosine-protein kinase Lck
Ligand
BDBM50593040
Substrate
n/a
Meas. Tech.
ChEMBL_2206814 (CHEMBL5119522)
IC50
140±n/a nM
Citation
 Ito, T; Kinoshita, K; Tomizawa, M; Shinohara, S; Nishii, H; Matsushita, M; Hattori, K; Kohchi, Y; Kohchi, M; Hayase, T; Watanabe, F; Hasegawa, K; Tanaka, H; Kuramoto, S; Takanashi, K; Oikawa, N Discovery of CH7057288 as an Orally Bioavailable, Selective, and Potent pan-TRK Inhibitor. J Med Chem 65:12427-12444 (2022) [PubMed] 
Target
Name:
Tyrosine-protein kinase Lck
Synonyms:
2.7.10.2 | LCK | LCK_HUMAN | LSK | Leukocyte C-terminal Src kinase | Lymphocyte cell-specific protein-tyrosine kinase | Lymphocyte-specific protein tyrosine kinase | P56-LCK | Protein YT16 | Proto-oncogene Lck | Proto-oncogene tyrosine-protein kinase LCK | Src/Lck kinase | T cell-specific protein-tyrosine kinase
Type:
n/a
Mol. Mass.:
57987.83
Organism:
Homo sapiens (Human)
Description:
P06239
Residue:
509
Sequence:
MGCGCSSHPEDDWMENIDVCENCHYPIVPLDGKGTLLIRNGSEVRDPLVTYEGSNPPASPLQDNLVIALHSYEPSHDGDLGFEKGEQLRILEQSGEWWKAQSLTTGQEGFIPFNFVAKANSLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQGEVVKHYKIRNLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRLSRPCQTQKPQKPWWEDEWEVPRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFLAEANLMKQLQHQRLVRLYAVVTQEPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEELYQLMRLCWKERPEDRPTFDYLRSVLEDFFTATEGQYQPQP
  
Inhibitor
Name:
BDBM50593040
Synonyms:
CHEMBL5189733
Type:
Small organic molecule
Emp. Form.:
C36H33N3O6
Mol. Mass.:
603.6637
SMILES:
CC1(C)NC(=O)N(CCOc2ccc3C(=O)c4c(oc5cc(ccc45)C#Cc4cc(OCC5CC5)ccn4)C(C)(C)c3c2)C1=O
Structure:
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