Reaction Details Report a problem with these data
Target
Sigma non-opioid intracellular receptor 1
Ligand
BDBM50593147
Substrate
n/a
Meas. Tech.
ChEMBL_2207448 (CHEMBL5120156)
Ki
24±n/a nM
Citation
 Turgutalp, B; Bhattarai, P; Ercetin, T; Luise, C; Reis, R; Gurdal, EE; Isaak, A; Biriken, D; Dinter, E; Sipahi, H; Schepmann, D; Junker, A; Wünsch, B; Sippl, W; Gulcan, HO; Kizil, C; Yarim, M Discovery of Potent Cholinesterase Inhibition-Based Multi-Target-Directed Lead Compounds for Synaptoprotection in Alzheimer's Disease. J Med Chem 65:12292-12318 (2022) [PubMed] 
Target
Name:
Sigma non-opioid intracellular receptor 1
Synonyms:
OPRS1 | SGMR1_CAVPO | SIGMAR1 | Sigma 1-type opioid receptor | Sigma non-opioid intracellular receptor 1 | Sigma-1 receptor | Sigma1-receptor | Sigma1R | Sterol isomerase-like protein
Type:
Protein
Mol. Mass.:
25307.17
Organism:
Cavia porcellus (Guinea pig)
Description:
Q60492
Residue:
223
Sequence:
MQWAVGRRWLWVALFLAAVAVLTQIVWLWLGTQNFVFQREEIAQLARQYAGLDHELAFSKLIVELRRLHPVHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSPRHSGRYWAEISDTIISGTFHQWREGTTKSEVFYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPSTLGFALADTVFSTQDFLTLFYTLRVYARALQLELTTYLFGQDP
  
Inhibitor
Name:
BDBM50593147
Synonyms:
CHEMBL5203777
Type:
Small organic molecule
Emp. Form.:
C21H30N4OS
Mol. Mass.:
386.554
SMILES:
Cc1cccc2sc(NC(=O)CCN3CCN(CC3)C3CCCCC3)nc12
Structure:
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