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Target
Dual specificity protein kinase CLK2
Ligand
BDBM50292406
Substrate
n/a
Meas. Tech.
ChEMBL_2214243 (CHEMBL5127375)
IC50
940±n/a nM
Citation
 Tahtouh, T; Durieu, E; Villiers, B; Bruyère, C; Nguyen, TL; Fant, X; Ahn, KH; Khurana, L; Deau, E; Lindberg, MF; Sévère, E; Miege, F; Roche, D; Limanton, E; L'Helgoual'ch, JM; Burgy, G; Guiheneuf, S; Herault, Y; Kendall, DA; Carreaux, F; Bazureau, JP; Meijer, L Structure-Activity Relationship in the Leucettine Family of Kinase Inhibitors. J Med Chem 65:1396-1417 (2022) [PubMed] 
Target
Name:
Dual specificity protein kinase CLK2
Synonyms:
CDC-like kinase 2 | CLK2_MOUSE | Clk2
Type:
PROTEIN
Mol. Mass.:
60021.57
Organism:
Mus musculus
Description:
ChEMBL_1502246
Residue:
499
Sequence:
MPHPRRYHSSERGSRGSYHEHYQSRKHKRRRSRSWSSSSDRTRRRRREDSYHVRSRSSYDDHSSDRRLYDRRYCGSYRRNDYSRDRGEAYYDTDFRQSYEYHRENSSYRSQRSSRRKHRRRRRRSRTFSRSSSHSSRRAKSVEDDAEGHLIYHVGDWLQERYEIVSTLGEGTFGRVVQCVDHRRGGTQVALKIIKNVEKYKEAARLEINVLEKINEKDPDNKNLCVQMFDWFDYHGHMCISFELLGLSTFDFLKDNNYLPYPIHQVRHMAFQLCQAVKFLHDNKLTHTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAVRVVDFGSATFDHEHHSTIVSTRHYRAPEVILELGWSQPCDVWSIGCIIFEYYVGFTLFQTHDNREHLAMMERILGPVPSRMIRKTRKQKYFYRGRLDWDENTSAGRYVRENCKPLRRYLTSEAEDHHQLFDLIENMLEYEPAKRLTLGEALQHPFFACLRTEPPNTKLWDSSRDISR
  
Inhibitor
Name:
BDBM50292406
Synonyms:
CHEMBL485053 | leucettamine B
Type:
Small organic molecule
Emp. Form.:
C12H11N3O3
Mol. Mass.:
245.234
SMILES:
CN1C(N)=NC(=Cc2ccc3OCOc3c2)C1=O |w:6.6,c:3|
Structure:
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