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Target
Melanocortin receptor 4
Ligand
BDBM50170433
Substrate
n/a
Meas. Tech.
ChEMBL_306119 (CHEMBL830069)
IC50
4.7±n/a nM
Citation
 Ujjainwalla, F; Warner, D; Snedden, C; Grisson, RD; Walsh, TF; Wyvratt, MJ; Kalyani, RN; Macneil, T; Tang, R; Weinberg, DH; Van der Ploeg, L; Goulet, MT Design and syntheses of melanocortin subtype-4 receptor agonists. Part 2: discovery of the dihydropyridazinone motif. Bioorg Med Chem Lett 15:4023-8 (2005) [PubMed]  Article 
Target
Name:
Melanocortin receptor 4
Synonyms:
MC4-R | MC4R | MC4R_HUMAN | Melanocortin MC4 | Melanocortin receptor 4 (MC-4) | Melanocortin receptor 4 (MC4-R) | Melanocortin receptor 4 (MC4R)
Type:
Enzyme
Mol. Mass.:
36949.50
Organism:
Homo sapiens (Human)
Description:
P32245
Residue:
332
Sequence:
MVNSTHRGMHTSLHLWNRSSYRLHSNASESLGKGYSDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVKRVGIIISCIWAACTVSGILFIIYSDSSAVIICLITMFFTMLALMASLYVHMFLMARLHIKRIAVLPGTGAIRQGANMKGAITLTILIGVFVVCWAPFFLHLIFYISCPQNPYCVCFMSHFNLYLILIMCNSIIDPLIYALRSQELRKTFKEIICCYPLGGLCDLSSRY
  
Inhibitor
Name:
BDBM50170433
Synonyms:
(4R,5S)-4-(4-Fluoro-phenyl)-1-methyl-piperidine-3-carboxylic acid {(R)-3-[6-(4-chloro-phenylsulfanyl)-2-(4-methoxy-phenyl)-3-oxo-2,3-dihydro-pyridazin-4-yl]-1-methyl-propyl}-amide | CHEMBL186557
Type:
Small organic molecule
Emp. Form.:
C34H36ClFN4O3S
Mol. Mass.:
635.191
SMILES:
COc1ccc(cc1)-n1nc(Sc2ccc(Cl)cc2)cc(CC[C@@H](C)NC(=O)[C@H]2CN(C)CC[C@@H]2c2ccc(F)cc2)c1=O
Structure:
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