Reaction Details Report a problem with these data
Target
Glucagon receptor
Ligand
BDBM50171825
Substrate
n/a
Meas. Tech.
ChEMBL_322388 (CHEMBL856252)
IC50
353±n/a nM
Citation
 Shen, DM; Zhang, F; Brady, EJ; Candelore, MR; Dallas-Yang, Q; Ding, VD; Dragovic, J; Feeney, WP; Jiang, G; McCann, PE; Mock, S; Qureshi, SA; Saperstein, R; Shen, X; Tamvakopoulos, C; Tong, X; Tota, LM; Wright, MJ; Yang, X; Zheng, S; Chapman, KT; Zhang, BB; Tata, JR; Parmee, ER Discovery of novel, potent, and orally active spiro-urea human glucagon receptor antagonists. Bioorg Med Chem Lett 15:4564-9 (2005) [PubMed]  Article 
Target
Name:
Glucagon receptor
Synonyms:
GCGR | GL-R | GLR_HUMAN | Glucagon Receptor (GCGR) | Glucagon receptor (GlucR)
Type:
Enzyme
Mol. Mass.:
54026.92
Organism:
Homo sapiens (Human)
Description:
P47871
Residue:
477
Sequence:
MPPCQPQRPLLLLLLLLACQPQVPSAQVMDFLFEKWKLYGDQCHHNLSLLPPPTELVCNRTFDKYSCWPDTPANTTANISCPWYLPWHHKVQHRFVFKRCGPDGQWVRGPRGQPWRDASQCQMDGEEIEVQKEVAKMYSSFQVMYTVGYSLSLGALLLALAILGGLSKLHCTRNAIHANLFASFVLKASSVLVIDGLLRTRYSQKIGDDLSVSTWLSDGAVAGCRVAAVFMQYGIVANYCWLLVEGLYLHNLLGLATLPERSFFSLYLGIGWGAPMLFVVPWAVVKCLFENVQCWTSNDNMGFWWILRFPVFLAILINFFIFVRIVQLLVAKLRARQMHHTDYKFRLAKSTLTLIPLLGVHEVVFAFVTDEHAQGTLRSAKLFFDLFLSSFQGLLVAVLYCFLNKEVQSELRRRWHRWRLGKVLWEERNTSNHRASSSPGHGPPSKELQFGRGGGSQDSSAETPLAGGLPRLAESPF
  
Inhibitor
Name:
BDBM50171825
Synonyms:
4-[8-tert-Butyl-3-(3-chloro-phenyl)-2-oxo-1,3-diaza-spiro[4.5]dec-1-ylmethyl]-N-(2H-tetrazol-5-yl)-benzamide | CHEMBL371476
Type:
Small organic molecule
Emp. Form.:
C27H32ClN7O2
Mol. Mass.:
522.042
SMILES:
CC(C)(C)C1CCC2(CN(C(=O)N2Cc2ccc(cc2)C(=O)Nc2nnn[nH]2)c2cccc(Cl)c2)CC1 |(2.25,-7.02,;1.17,-5.92,;.08,-7.02,;.08,-4.83,;2.26,-4.86,;3.47,-3.16,;4.97,-4.09,;7.2,-3.81,;7.66,-2.35,;9.2,-2.35,;9.68,-3.81,;11.12,-4.3,;8.43,-4.72,;8.43,-6.25,;9.75,-7.02,;11.08,-6.23,;12.41,-6.99,;12.41,-8.55,;11.08,-9.31,;9.75,-8.55,;13.74,-9.31,;13.74,-10.84,;15.07,-8.52,;16.39,-9.29,;16.57,-10.82,;18.06,-11.12,;18.83,-9.8,;17.8,-8.66,;10.1,-1.12,;9.47,.27,;10.36,1.5,;11.9,1.36,;12.53,-.05,;14.05,-.22,;11.62,-1.28,;5.9,-5.09,;4.45,-4.56,)|
Structure:
Search PDB for entries with ligand similarity: