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Target
Peroxisome proliferator-activated receptor delta
Ligand
BDBM28661
Substrate
n/a
Meas. Tech.
ChEMBL_2220576 (CHEMBL5133910)
EC50
76±n/a nM
Citation
 Kato, T; Ohara, T; Suzuki, N; Muto, S; Tokuyama, R; Mizutani, M; Fukasawa, H; Matsumura, KI; Itai, A Discovery and structure-based design of a new series of potent and selective PPAR? agonists utilizing a virtual screening method. Bioorg Med Chem Lett 59:0 (2022) [PubMed] 
Target
Name:
Peroxisome proliferator-activated receptor delta
Synonyms:
NUC1 | Nr1c2 | Nuclear hormone receptor 1 | Nuclear receptor subfamily 1 group C member 2 | PPAR-beta | PPAR-delta | PPARD_MOUSE | Pparb | Ppard
Type:
PROTEIN
Mol. Mass.:
49719.14
Organism:
Mus musculus
Description:
ChEMBL_1288931
Residue:
440
Sequence:
MEQPQEETPEAREEEKEEVAMGDGAPELNGGPEHTLPSSSCADLSQNSSPSSLLDQLQMGCDGASGGSLNMECRVCGDKASGFHYGVHACEGCKGFFRRTIRMKLEYEKCDRICKIQKKNRNKCQYCRFQKCLALGMSHNAIRFGRMPEAEKRKLVAGLTASEGCQHNPQLADLKAFSKHIYNAYLKNFNMTKKKARSILTGKSSHNAPFVIHDIETLWQAEKGLVWKQLVNGLPPYNEISVHVFYRCQSTTVETVRELTEFAKNIPNFSSLFLNDQVTLLKYGVHEAIFAMLASIVNKDGLLVANGSGFVTHEFLRSLRKPFSDIIEPKFEFAVKFNALELDDSDLALFIAAIILCGDRPGLMNVPQVEAIQDTILRALEFHLQVNHPDSQYLFPKLLQKMADLRQLVTEHAQMMQWLKKTESETLLHPLLQEIYKDMY
  
Inhibitor
Name:
BDBM28661
Synonyms:
2-{2-methyl-4-[({4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl}methyl)sulfanyl]phenoxy}acetic acid | CHEMBL38943 | GW 501516 | GW-501516 | GW1516 | GW501516
Type:
Small organic molecule
Emp. Form.:
C21H18F3NO3S2
Mol. Mass.:
453.498
SMILES:
Cc1nc(sc1CSc1ccc(OCC(O)=O)c(C)c1)-c1ccc(cc1)C(F)(F)F
Structure:
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