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Target
5-hydroxytryptamine receptor 6
Ligand
BDBM50172306
Substrate
n/a
Meas. Tech.
ChEMBL_320876 (CHEMBL884801)
Ki
22.7±n/a nM
Citation
 Cole, DC; Lennox, WJ; Stock, JR; Ellingboe, JW; Mazandarani, H; Smith, DL; Zhang, G; Tawa, GJ; Schechter, LE Conformationally constrained N1-arylsulfonyltryptamine derivatives as 5-HT6 receptor antagonists. Bioorg Med Chem Lett 15:4780-5 (2005) [PubMed]  Article 
Target
Name:
5-hydroxytryptamine receptor 6
Synonyms:
5-HT-6 | 5-HT6 | 5-hydroxytryptamine receptor 6 (5-HT-6) | 5-hydroxytryptamine receptor 6 (5-HT6R) | 5-hydroxytryptamine receptor 6 (5HT6) | 5HT6R_HUMAN | HTR6 | Serotonin (5-HT3) receptor | Serotonin 6 (5-HT6) receptor | Serotonin Receptor 6
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
46968.43
Organism:
Homo sapiens (Human)
Description:
P50406
Residue:
440
Sequence:
MVPEPGPTANSTPAWGAGPPSAPGGSGWVAAALCVVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSASILNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFLPLLLGWHELGHARPPVPGQCRLLASLPFVLVASGLTFFLPSGAICFTYCRILLAARKQAVQVASLTTGMASQASETLQVPRTPRPGVESADSRRLATKHSRKALKASLTLGILLGMFFVTWLPFFVANIVQAVCDCISPGLFDVLTWLGYCNSTMNPIIYPLFMRDFKRALGRFLPCPRCPRERQASLASPSLRTSHSGPRPGLSLQQVLPLPLPPDSDSDSDAGSGGSSGLRLTAQLLLPGEATQDPPLPTRAAAAVNFFNIDPAEPELRPHPLGIPTN
  
Inhibitor
Name:
BDBM50172306
Synonyms:
1-(5-Chloro-thiophene-2-sulfonyl)-3-(1,2,5,6-tetrahydro-pyridin-3-yl)-1H-indole | CHEMBL362921
Type:
Small organic molecule
Emp. Form.:
C17H15ClN2O2S2
Mol. Mass.:
378.896
SMILES:
Clc1ccc(s1)S(=O)(=O)n1cc(C2=CCCNC2)c2ccccc12 |t:13|
Structure:
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