Reaction Details Report a problem with these data
Target
Carbonic anhydrase 2
Ligand
BDBM50174041
Substrate
n/a
Meas. Tech.
ChEMBL_320718 (CHEMBL881704)
Ki
1±n/a nM
Citation
 Ozensoy, O; Puccetti, L; Fasolis, G; Arslan, O; Scozzafava, A; Supuran, CT Carbonic anhydrase inhibitors: inhibition of the tumor-associated isozymes IX and XII with a library of aromatic and heteroaromatic sulfonamides. Bioorg Med Chem Lett 15:4862-6 (2005) [PubMed]  Article 
Target
Name:
Carbonic anhydrase 2
Synonyms:
CA-II | CA2 | CAC | CAH2_HUMAN | Carbonate dehydratase II | Carbonic anhydrase 2 (CA II) | Carbonic anhydrase 2 (CA-II) | Carbonic anhydrase 2 (Recombinant CA II) | Carbonic anhydrase C | Carbonic anhydrase II (CA II) | Carbonic anhydrase II (CA-II) | Carbonic anhydrase II (CAII) | Carbonic anhydrase II (hCA II) | Carbonic anhydrase isoenzyme II (hCA II)
Type:
Enzyme
Mol. Mass.:
29250.71
Organism:
Homo sapiens (Human)
Description:
P00918
Residue:
260
Sequence:
MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK
  
Inhibitor
Name:
BDBM50174041
Synonyms:
5-(4-Nitro-cyclohexa-2,4-dienesulfinylamino)-[1,3,4]thiadiazole-2-sulfonic acid amide | CHEMBL382075
Type:
Small organic molecule
Emp. Form.:
C8H7N5O5S3
Mol. Mass.:
349.367
SMILES:
NS(=O)(=O)c1nnc(NS(=O)c2ccc(cc2)[N+]([O-])=O)s1
Structure:
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